| Status | Available to order |
| EMMA ID | EM:08021 |
| Citation information | RRID:IMSR_EM:08021 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129(Cg)-Tectatm4.1Gpr/GprH |
| Alternative name | Tecta |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Tectatm4.1Gpr |
| Gene/Transgene symbol | Tecta |
| Provider | Guy Richardson |
| Provider affiliation | School of Life Sciences, University of Sussex |
| Genetic information | Exon 17 was replaced with one in which two point mutations (C>T and G>A) results in the amino acid substitutions of phenylalanine for leucine at position 1820 (L1820F) and aspartic acid for glycine at position 1824 (G1824D). Cre-mediated recombination was used to remove the neomycin resistance cassette after correct targeting was confirmed. |
| Phenotypic information | Homozygous:In Tecta |
| Breeding history | F1 mice from germline transmitting chimera were mated with a Cre deleter line to remove the floxed neomycin resistance cassette and the F2 generation then outbred to 129SvEv. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
