- audiogenic seizures / MGI
- abnormal tectorial membrane morphology / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- impaired hearing / MGI
- increased or absent threshold for auditory brainstem response / MGI
- abnormal Hensen stripe morphology / MGI
- abnormal tectorial membrane marginal band morphology / MGI
- abnormal tectorial membrane covernet morphology / MGI
129(Cg)-Tectatm3.1Gpr/GprH
Status | Available to order |
EMMA ID | EM:08019 |
International strain name | 129(Cg)-Tectatm3.1Gpr/GprH |
Alternative name | Tecta |
Strain type | Targeted Mutant Strains : Point mutation |
Allele/Transgene symbol | Tectatm3.1Gpr |
Gene/Transgene symbol | Tecta |
Information from provider
Provider | Guy Richardson |
Provider affiliation | School of Life Sciences, University of Sussex |
Genetic information | Exon 14 was replaced with one in which a point mutation (G to C) results in the amino acid substitution of serine for cysteine at position 1619 (C1619S); cre-mediated recombination removed the neomycin resistance cassette. |
Phenotypic information | Homozygous:In Tecta |
Breeding history | F1 mice from germline transmitting chimera were mated with a cre recombinase deleter line to remove the floxed neomycin resistance cassette and the F2 generation was then outbred to 129SvEv. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- audiogenic seizures / MGI
- abnormal hearing physiology / MGI
- abnormal otolithic membrane morphology / MGI
- no phenotypic analysis / MGI
- enlarged otoliths / MGI
- decreased otolith number / MGI
- abnormal tectorial membrane morphology / MGI
- detached tectorial membrane / MGI
- abnormal cochlear microphonics / MGI
- decreased cochlear microphonics / MGI
- decreased cochlear nerve compound action potential / MGI
- abnormal hair cell mechanoelectric transduction / MGI
- abnormal cochlear outer hair cell physiology / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- abnormal distortion product otoacoustic emission / MGI
- absent distortion product otoacoustic emissions / MGI
- hearing/vestibular/ear phenotype / MGI
- behavior/neurological phenotype / MGI
- impaired hearing / MGI
- abnormal otoacoustic response / MGI
- increased or absent threshold for auditory brainstem response / MGI
- abnormal Hensen stripe morphology / MGI
- absent Hensen stripe / MGI
- abnormal Kimura membrane morphology / MGI
- abnormal tectorial membrane marginal band morphology / MGI
- abnormal tectorial membrane covernet morphology / MGI
- abnormal tectorial membrane striated-sheet matrix morphology / MGI
Literature references
- Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane.;Legan P Kevin, Goodyear Richard J, Morín Matías, Mencia Angeles, Pollard Hilary, Olavarrieta Leticia, Korchagina Julia, Modamio-Hoybjor Silvia, Mayo Fernando, Moreno Felipe, Moreno-Pelayo Miguel-Angel, Richardson Guy P, ;2014;Human molecular genetics;23;2551-68; 24363064
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