| Status | Available to order |
| EMMA ID | EM:08019 |
| Citation information | RRID:IMSR_EM:08019 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129(Cg)-Tectatm3.1Gpr/GprH |
| Alternative name | Tecta |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Tectatm3.1Gpr |
| Gene/Transgene symbol | Tecta |
| Provider | Guy Richardson |
| Provider affiliation | School of Life Sciences, University of Sussex |
| Genetic information | Exon 14 was replaced with one in which a point mutation (G to C) results in the amino acid substitution of serine for cysteine at position 1619 (C1619S); cre-mediated recombination removed the neomycin resistance cassette. |
| Phenotypic information | Homozygous: In Tecta Heterozygous: In heterozygous mice inner ear phenotype shows malformation of the tectorial membrane, auditory brainstem response (ABR) thresholds elevated by 20-30 dB and an enhanced susceptibility to audiogenic seizure at low sound pressure level. |
| Breeding history | F1 mice from germline transmitting chimera were mated with a cre recombinase deleter line to remove the floxed neomycin resistance cassette and the F2 generation was then outbred to 129SvEv. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
