C57BL/6N-Reltm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:07990
International strain nameC57BL/6N-Reltm1a(EUCOMM)Wtsi/H
Alternative nameEPD0463_4_D10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolReltm1a(EUCOMM)Wtsi
Gene/Transgene symbolRel
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0463_4_D10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • impaired glucose tolerance / IMPC
  • tremors / IMPC
  • absent vibrissae / IMPC
  • decreased monocyte cell number / IMPC
MGI phenotypes (gene matching)
  • extramedullary hematopoiesis / MGI
  • decreased bone marrow cell number / MGI
  • abnormal stomach morphology / MGI
  • abnormal liver morphology / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • abnormal lung morphology / MGI
  • dermatitis / MGI
  • impaired hematopoiesis / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal leukocyte physiology / MGI
  • abnormal T cell physiology / MGI
  • abnormal macrophage morphology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal professional antigen presenting cell physiology / MGI
  • decreased IgE level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • abnormal cytokine secretion / MGI
  • abnormal cell cycle / MGI
  • increased neuron apoptosis / MGI
  • impaired macrophage chemotaxis / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased B-1 B cell number / MGI
  • increased eosinophil cell number / MGI
  • increased T cell number / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased cytotoxic T cell cytolysis / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal skeleton morphology / MGI
  • decreased apoptosis / MGI
  • abnormal DNA replication / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal T-helper 1 cell differentiation / MGI
  • abnormal memory B cell number / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • decreased spleen germinal center number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased IgG2a level / MGI
  • abnormal splenic cell ratio / MGI
  • increased effector memory CD4-positive, alpha-beta T cell number / MGI
  • decreased response to antigen / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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