C57BL/6N-A^tm1Brd 1700007K13Rik^{tm2a(EUCOMM)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:07969
Citation information	RRID:IMSR_EM:07969 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-A^tm1Brd 1700007K13Rik^{tm2a(EUCOMM)Wtsi}/WtsiH
Alternative name	EPD0968_5_H07
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	1700007K13Rik^{tm2a(EUCOMM)Wtsi}
Gene/Transgene symbol	1700007K13Rik
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from EUCOMM ES clone EPD0968_5_H07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)

abnormal heart morphology / MGI
abnormal mitral valve morphology / MGI
right pulmonary isomerism / MGI
dextrocardia / MGI
mesocardia / MGI
abnormal spleen morphology / MGI
abnormal left-right axis patterning / MGI
abnormal kidney morphology / MGI
no abnormal phenotype detected / MGI
persistent truncus arteriosis / MGI
heart hypoplasia / MGI
dilated heart atrium / MGI
left pulmonary isomerism / MGI
abnormal heart left ventricle morphology / MGI
abnormal primitive node morphology / MGI
heterotaxia / MGI
abnormal liver lobule morphology / MGI
abnormal lateral plate mesoderm morphology / MGI
ventricular septal defect / MGI
muscular ventricular septal defect / MGI
abnormal aortic valve cusp morphology / MGI
right-sided stomach / MGI
abnormal lung position or orientation / MGI
abnormal lung lobe morphology / MGI
lethality throughout fetal growth and development, incomplete penetrance / MGI
situs inversus totalis / MGI
absent segment of posterior cerebral artery / MGI
retropleural edema / MGI
blood in lymph vessels / MGI
abnormal vertebral artery topology / MGI
heterochrony / MGI
left sided inferior vena cava / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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