C57BL/6N-Atm1Brd Adcy9tm1a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:07963
International strain nameC57BL/6N-Atm1Brd Adcy9tm1a(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0382_6_B06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAdcy9tm1a(EUCOMM)Wtsi
Gene/Transgene symbolAdcy9
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0382_6_B06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased circulating chloride level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased circulating insulin level / IMPC
MGI phenotypes (gene matching)
  • abnormal small intestine placement / MGI
  • enlarged liver sinusoidal spaces / MGI
  • small superior cervical ganglion / MGI
  • no abnormal phenotype detected / MGI
  • abnormal Mullerian duct morphology / MGI
  • liver hemorrhage / MGI
  • absent stapedial artery / MGI
  • abnormal temporal bone morphology / MGI
  • increased IgG1 level / MGI
  • abnormal right lung accessory lobe morphology / MGI
  • perimembraneous ventricular septal defect / MGI
  • dual inferior vena cava / MGI
  • absent segment of posterior cerebral artery / MGI
  • retropleural edema / MGI
  • abnormal Mullerian duct topology / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve morphology / MGI
  • blood in lymph vessels / MGI
  • abnormal umbilical vein topology / MGI
  • abnormal vertebral artery topology / MGI
  • additional anastomosis between intracranial vertebral arteries / MGI
  • retrolental blood / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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