C57BL/6N-Atm1Brd Ccdc134tm1a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:07959
Citation informationRRID:IMSR_EM:07959 

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International strain nameC57BL/6N-Atm1Brd Ccdc134tm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0293_1_D11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCcdc134tm1a(KOMP)Wtsi
Gene/Transgene symbolCcdc134
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0293_1_D11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased grip strength / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • increased grip strength / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal vascular development / MGI
  • liver hypoplasia / MGI
  • small liver / MGI
  • anemia / MGI
  • abnormal blood vessel morphology / MGI
  • cardiac hypertrophy / MGI
  • decreased embryo size / MGI
  • intracranial hemorrhage / MGI
  • abnormal brain morphology / MGI
  • decreased hepatocyte proliferation / MGI
  • small placenta / MGI
  • abnormal brain vasculature morphology / MGI
  • abnormal trophoblast layer morphology / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal placenta fetal blood space morphology / MGI

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Practical information

Genotyping protocol

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