C57BL/6N-Chrnb2tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:07867
International strain nameC57BL/6N-Chrnb2tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0739_7_H05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolChrnb2tm1a(EUCOMM)Hmgu
Gene/Transgene symbolChrnb2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0739_7_H05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal epididymis morphology / IMPC
  • persistence of hyaloid vascular system / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • increased total body fat amount / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • enlarged heart / IMPC
MGI phenotypes (gene matching)
  • abnormal superior colliculus morphology / MGI
  • abnormal social investigation / MGI
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • abnormal response to new environment / MGI
  • abnormal immune system physiology / MGI
  • apnea / MGI
  • decreased chemically-elicited antinociception / MGI
  • abnormal associative learning / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal tidal volume / MGI
  • abnormal pulmonary ventilation / MGI
  • decreased immunoglobulin level / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgG level / MGI
  • abnormal response to novelty / MGI
  • enhanced coordination / MGI
  • impaired passive avoidance behavior / MGI
  • abnormal lateral geniculate nucleus morphology / MGI
  • abnormal behavior / MGI
  • decreased B cell number / MGI
  • increased B cell proliferation / MGI
  • decreased susceptibility to injury / MGI
  • homeostasis/metabolism phenotype / MGI
  • behavior/neurological phenotype / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal eye electrophysiology / MGI
  • increased pulmonary ventilation / MGI
  • increased tidal volume / MGI
  • decreased visual acuity / MGI
  • fragmentation of sleep/wake states / MGI
  • abnormal nicotine-mediated receptor currents / MGI
  • myeloid hyperplasia / MGI
  • decreased erythroblast number / MGI
  • abnormal habituation to a new environment / MGI
  • enhanced spatial learning / MGI
  • increased susceptibility to induction of seizure by inducing agent / MGI
  • abnormal behavioral response to nicotine / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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