C57BL/6N-Jag2tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:07862
International strain nameC57BL/6N-Jag2tm1a(KOMP)Wtsi/H
Alternative nameEPD0703_1_B11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolJag2tm1a(KOMP)Wtsi
Gene/Transgene symbolJag2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0703_1_B11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • absent maxillary shelf / MGI
  • absent palatine bone horizontal plate / MGI
  • syndactyly / MGI
  • abnormal autopod morphology / MGI
  • kinked tail / MGI
  • abnormal thymus morphology / MGI
  • epidermal hyperplasia / MGI
  • cyanosis / MGI
  • abnormal apical ectodermal ridge morphology / MGI
  • thick apical ectodermal ridge / MGI
  • female infertility / MGI
  • respiratory distress / MGI
  • abnormal tail morphology / MGI
  • abnormal thymus medulla morphology / MGI
  • abnormal caudal vertebrae morphology / MGI
  • no phenotypic analysis / MGI
  • parakeratosis / MGI
  • increased cochlear inner hair cell number / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • increased cochlear outer hair cell number / MGI
  • increased cochlear hair cell number / MGI
  • abnormal orientation of inner hair cell stereociliary bundles / MGI
  • decreased organ of Corti supporting cell number / MGI
  • abnormal orientation of cochlear hair cell stereociliary bundles / MGI
  • abnormal embryonic autopod plate morphology / MGI
  • abnormal phalanx morphology / MGI
  • abnormal limb bud morphology / MGI
  • abnormal digit development / MGI
  • decreased gamma-delta T cell number / MGI
  • abnormal gamma-delta T cell differentiation / MGI
  • fused phalanges / MGI
  • fused tarsal bones / MGI
  • palatal shelf fusion with tongue or mandible / MGI
  • failure of palatal shelf elevation / MGI
  • cleft secondary palate / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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