STOCK Eif6^tm1Sbif/Cnrm

Status	Available to order
EMMA ID	EM:07840
International strain name	STOCK Eif6^tm1Sbif/Cnrm
Alternative name	eIF6 knockout mice
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Eif6^tm1Sbif
Gene/Transgene symbol	Eif6

Information from provider

Provider	STEFANO BIFFO
Provider affiliation	San Raffaele Scientific Institute
Genetic information	Heterozygous mice for the eIF6 gene. Null mice lethal. - Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, Amati B, de Marco A, Biffo S. Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. Cancer Cell. 2011 Jun 14;19(6):765-75. doi: 10.1016/j.ccr.2011.04.018. PubMed PMID:21665150. - Gandin V, Miluzio A, Barbieri AM, Beugnet A, Kiyokawa H, Marchisio PC, Biffo S. Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature. 2008 Oct 2;455(7213):684-8. doi: 10.1038/nature07267. Epub 2008 Sep 10. PubMed PMID: 18784653; PubMed Central PMCID: PMC2753212.
Phenotypic information	Homozygous: Null lethal at preimplantation. Heterozygous: Resistant to tumorigenesis; less fat; switch in metabolism (unpublished; Nature, submitted). See also: - Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, Amati B, de Marco A, Biffo S. Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. Cancer Cell. 2011 Jun 14;19(6):765-75. doi: 10.1016/j.ccr.2011.04.018. PubMed PMID: 21665150. - Gandin V, Miluzio A, Barbieri AM, Beugnet A, Kiyokawa H, Marchisio PC, Biffo S. Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature. 2008 Oct 2;455(7213):684-8. doi: 10.1038/nature07267. Epub 2008 Sep 10. PubMed PMID: 18784653; PubMed Central PMCID: PMC2753212.
References	Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.;Miluzio Annarita, Beugnet Anne, Grosso Stefano, Brina Daniela, Mancino Marilena, Campaner Stefano, Amati Bruno, de Marco Ario, Biffo Stefano, ;2011;Cancer cell;19;765-75; 21665150 Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.;Gandin Valentina, Miluzio Annarita, Barbieri Anna Maria, Beugnet Anne, Kiyokawa Hiroaki, Marchisio Pier Carlo, Biffo Stefano, ;2008;Nature;455;684-8; 18784653 Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.;Manfrini Nicola, Ricciardi Sara, Miluzio Annarita, Fedeli Maya, Scagliola Alessandra, Gallo Simone, Adler Thure, Busch Dirk H, Gailus-Durner Valerie, Fuchs Helmut, de Angelis Martin Hrabě, Biffo Stefano, ;2017;Data in brief;14;653-658; 28924581 eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.;Brina Daniela, Miluzio Annarita, Ricciardi Sara, Clarke Kim, Davidsen Peter K, Viero Gabriella, Tebaldi Toma, Offenhäuser Nina, Rozman Jan, Rathkolb Birgit, Neschen Susanne, Klingenspor Martin, Wolf Eckhard, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Quattrone Alessandro, Falciani Francesco, Biffo Stefano, ;2015;Nature communications;6;8261; 26383020
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)

liver hypoplasia / MGI
decreased body weight / MGI
decreased liver weight / MGI
abnormal mitosis / MGI
abnormal cell physiology / MGI
abnormal fat cell morphology / MGI
decreased total body fat amount / MGI
abnormal hepatocyte physiology / MGI
embryonic lethality before implantation, complete penetrance / MGI

MGI phenotypes (gene matching)

liver hypoplasia / MGI
decreased body weight / MGI
decreased liver weight / MGI
abnormal mitosis / MGI
abnormal cell physiology / MGI
abnormal fat cell morphology / MGI
decreased total body fat amount / MGI
abnormal hepatocyte physiology / MGI
embryonic lethality before implantation, complete penetrance / MGI

Literature references

Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.;Miluzio Annarita, Beugnet Anne, Grosso Stefano, Brina Daniela, Mancino Marilena, Campaner Stefano, Amati Bruno, de Marco Ario, Biffo Stefano, ;2011;Cancer cell;19;765-75; 21665150
Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.;Gandin Valentina, Miluzio Annarita, Barbieri Anna Maria, Beugnet Anne, Kiyokawa Hiroaki, Marchisio Pier Carlo, Biffo Stefano, ;2008;Nature;455;684-8; 18784653
Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.;Manfrini Nicola, Ricciardi Sara, Miluzio Annarita, Fedeli Maya, Scagliola Alessandra, Gallo Simone, Adler Thure, Busch Dirk H, Gailus-Durner Valerie, Fuchs Helmut, de Angelis Martin Hrabě, Biffo Stefano, ;2017;Data in brief;14;653-658; 28924581
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.;Brina Daniela, Miluzio Annarita, Ricciardi Sara, Clarke Kim, Davidsen Peter K, Viero Gabriella, Tebaldi Toma, Offenhäuser Nina, Rozman Jan, Rathkolb Birgit, Neschen Susanne, Klingenspor Martin, Wolf Eckhard, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Quattrone Alessandro, Falciani Francesco, Biffo Stefano, ;2015;Nature communications;6;8261; 26383020

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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STOCK Eif6tm1Sbif/Cnrm