B6;129S4-Col1a1tm1(tetO-Vegfc)Mmul/Biat

Status

Available to order

EMMA IDEM:07833
International strain nameB6;129S4-Col1a1tm1(tetO-Vegfc)Mmul/Biat
Alternative nameB6N;129P2-Col1a1tm1(tetO-VEGFC)Biat
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolCol1a1tm1(tetO-Vegfc)Mmul
Gene/Transgene symbolCol1a1

Information from provider

ProviderMathias Mueller
Provider affiliationInstitute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
Genetic informationKH2 ES cells were targeted with a construct harbouring the tetO followed by the Vegfc cDNA into the Col1a1 locus (downstream of the polyA).
Phenotypic informationHomozygous:
There is no obvious phenotype.

Heterozygous:
Mice were kept so far heterozygous.
Breeding historyES cells were injected into blastocysts and resulting chimeras were crossed to C57BL/6N females. Transgenic offspring were mated with wild-type offspring (non siblings).
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal adipose tissue distribution / MGI
  • big ears / MGI
  • delayed bone ossification / MGI
  • fragile skeleton / MGI
  • increased bone mineral density / MGI
  • decreased bone mineral density / MGI
  • failure of bone resorption / MGI
  • osteopetrosis / MGI
  • kyphoscoliosis / MGI
  • abnormal neurocranium morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal vertebral body morphology / MGI
  • abnormal rib morphology / MGI
  • kyphosis / MGI
  • scoliosis / MGI
  • heart right ventricle hypertrophy / MGI
  • increased cell proliferation / MGI
  • abnormal cell morphology / MGI
  • focal hair loss / MGI
  • abnormal cranium morphology / MGI
  • abnormal maxilla morphology / MGI
  • abnormal digestive system morphology / MGI
  • abnormal forelimb morphology / MGI
  • abnormal femur morphology / MGI
  • syndactyly / MGI
  • oligodactyly / MGI
  • abnormal autopod morphology / MGI
  • thin tail / MGI
  • abnormal liver morphology / MGI
  • weakness / MGI
  • hindlimb paralysis / MGI
  • abnormal uterus morphology / MGI
  • lung hemorrhage / MGI
  • thick skin / MGI
  • skin hyperplasia / MGI
  • abnormal dermal layer morphology / MGI
  • thick dermal layer / MGI
  • increased body length / MGI
  • decreased body length / MGI
  • increased body weight / MGI
  • decreased body weight / MGI
  • increased body size / MGI
  • decreased body size / MGI
  • abnormal tail movements / MGI
  • abnormal locomotor behavior / MGI
  • hypoactivity / MGI
  • abnormal gait / MGI
  • abnormal motor coordination/balance / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal cardiovascular system physiology / MGI
  • abnormal blood vessel morphology / MGI
  • embryonic growth arrest / MGI
  • lung inflammation / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • increased litter size / MGI
  • decreased litter size / MGI
  • delayed sexual maturation / MGI
  • respiratory distress / MGI
  • abnormal coat/hair pigmentation / MGI
  • premature death / MGI
  • abnormal limb morphology / MGI
  • abnormal digit morphology / MGI
  • abnormal limb bone morphology / MGI
  • abnormal fertility/fecundity / MGI
  • no abnormal phenotype detected / MGI
  • abnormal fibula morphology / MGI
  • abnormal turbinate morphology / MGI
  • decreased susceptibility to hepatic steatosis / MGI
  • abnormal blood gas level / MGI
  • delayed vaginal opening / MGI
  • decreased circulating insulin level / MGI
  • abnormal mechanical nociception / MGI
  • decreased vertical activity / MGI
  • abnormal dental pulp cavity morphology / MGI
  • coarse hair / MGI
  • increased growth rate / MGI
  • increased insulin sensitivity / MGI
  • abnormal bone mineralization / MGI
  • increased circulating parathyroid hormone level / MGI
  • decreased circulating alkaline phosphatase level / MGI
  • arthritis / MGI
  • abnormal bone healing / MGI
  • no phenotypic analysis / MGI
  • decreased skin tensile strength / MGI
  • decreased tendon stiffness / MGI
  • short femur / MGI
  • decreased susceptibility to age related obesity / MGI
  • aneurysm / MGI
  • osteoarthritis / MGI
  • abnormal long bone morphology / MGI
  • abnormal compact bone morphology / MGI
  • abnormal forelimb zeugopod morphology / MGI
  • increased hepatocyte proliferation / MGI
  • abnormal hormone level / MGI
  • increased lean body mass / MGI
  • decreased thermal nociceptive threshold / MGI
  • decreased bone mass / MGI
  • aortic dissection / MGI
  • abnormal chest morphology / MGI
  • abnormal pubis morphology / MGI
  • abnormal ischium morphology / MGI
  • abnormal pelvic girdle bone morphology / MGI
  • thin ribs / MGI
  • rib fractures / MGI
  • decreased length of long bones / MGI
  • abnormal vertebral column morphology / MGI
  • short vertebral body / MGI
  • increased susceptibility to age-related hearing loss / MGI
  • abnormal osteoblast morphology / MGI
  • increased osteoblast cell number / MGI
  • decreased bone strength / MGI
  • increased bone resorption / MGI
  • abnormal osteoblast physiology / MGI
  • liver hyperplasia / MGI
  • decreased susceptibility to injury / MGI
  • ocular hypertension / MGI
  • improved glucose tolerance / MGI
  • abnormal humerus morphology / MGI
  • abnormal enzyme/coenzyme level / MGI
  • abnormal myocardium layer morphology / MGI
  • homeostasis/metabolism phenotype / MGI
  • hearing/vestibular/ear phenotype / MGI
  • digestive/alimentary phenotype / MGI
  • reproductive system phenotype / MGI
  • skeleton phenotype / MGI
  • vision/eye phenotype / MGI
  • decreased percent body fat/body weight / MGI
  • abnormal skeleton morphology / MGI
  • decreased circulating glucose level / MGI
  • decreased ventricle muscle contractility / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • spinal hemorrhage / MGI
  • abnormal heart septum morphology / MGI
  • impaired hearing / MGI
  • decreased diameter of femur / MGI
  • abnormal myometrium morphology / MGI
  • abnormal osteoblast differentiation / MGI
  • abnormal cutaneous collagen fibril morphology / MGI
  • abnormal osteocyte morphology / MGI
  • fused carpal bones / MGI
  • delayed female fertility / MGI
  • small pancreatic islets / MGI
  • decreased trabecular bone thickness / MGI
  • abnormal endoplasmic reticulum morphology / MGI
  • abnormal aorta elastic tissue morphology / MGI
  • abnormal aorta tunica adventitia morphology / MGI
  • decreased total body fat amount / MGI
  • abnormal thoracic cage shape / MGI
  • decreased bone mineral content / MGI
  • abnormal heart electrocardiography waveform feature / MGI
  • myocardial hypertrophy / MGI
  • increased QRS amplitude / MGI
  • abnormal bone trabecula morphology / MGI
  • decreased bone trabecula number / MGI
  • decreased bone volume / MGI
  • decreased trabecular bone volume / MGI
  • pulmonary alveolar hemorrhage / MGI
  • abnormal compact bone lamellar structure / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • abnormal bone collagen fibril morphology / MGI
  • abnormal tendon collagen fibril morphology / MGI
  • decreased neuronal stem cell self-renewal / MGI
  • thin body / MGI
  • abnormal extracellular matrix morphology / MGI
  • osteophytes / MGI
  • increased bone trabecular spacing / MGI
  • decreased bone trabecular spacing / MGI
  • decreased bone ossification / MGI
  • decreased bone mineralization / MGI
  • decreased collagen level / MGI
  • broad face / MGI
  • thick neurocranium / MGI
  • thin neurocranium / MGI
  • increased osteoblast apoptosis / MGI
  • abnormal dentin mineralization / MGI
  • increased osteocyte apoptosis / MGI
  • abnormal osteocyte lacuna morphology / MGI
  • joint contracture / MGI
  • atlanto-occipital joint dislocation / MGI
  • abnormal olecranon morphology / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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