- abnormal adipose tissue distribution / MGI
- big ears / MGI
- delayed bone ossification / MGI
- fragile skeleton / MGI
- increased bone mineral density / MGI
- decreased bone mineral density / MGI
- failure of bone resorption / MGI
- osteopetrosis / MGI
- kyphoscoliosis / MGI
- abnormal neurocranium morphology / MGI
- decreased compact bone thickness / MGI
- abnormal vertebral body morphology / MGI
- abnormal rib morphology / MGI
- kyphosis / MGI
- scoliosis / MGI
- heart right ventricle hypertrophy / MGI
- increased cell proliferation / MGI
- abnormal cell morphology / MGI
- focal hair loss / MGI
- abnormal cranium morphology / MGI
- abnormal maxilla morphology / MGI
- abnormal digestive system morphology / MGI
- abnormal forelimb morphology / MGI
- abnormal femur morphology / MGI
- syndactyly / MGI
- oligodactyly / MGI
- abnormal autopod morphology / MGI
- thin tail / MGI
- abnormal liver morphology / MGI
- weakness / MGI
- hindlimb paralysis / MGI
- abnormal uterus morphology / MGI
- lung hemorrhage / MGI
- thick skin / MGI
- skin hyperplasia / MGI
- abnormal dermal layer morphology / MGI
- thick dermal layer / MGI
- increased body length / MGI
- decreased body length / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased body size / MGI
- decreased body size / MGI
- abnormal tail movements / MGI
- abnormal locomotor behavior / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- abnormal motor coordination/balance / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal blood vessel morphology / MGI
- embryonic growth arrest / MGI
- lung inflammation / MGI
- hemorrhage / MGI
- intracranial hemorrhage / MGI
- increased litter size / MGI
- decreased litter size / MGI
- delayed sexual maturation / MGI
- respiratory distress / MGI
- abnormal coat/hair pigmentation / MGI
- premature death / MGI
- abnormal limb morphology / MGI
- abnormal digit morphology / MGI
- abnormal limb bone morphology / MGI
- abnormal fertility/fecundity / MGI
- no abnormal phenotype detected / MGI
- abnormal fibula morphology / MGI
- abnormal turbinate morphology / MGI
- decreased susceptibility to hepatic steatosis / MGI
- abnormal blood gas level / MGI
- delayed vaginal opening / MGI
- decreased circulating insulin level / MGI
- abnormal mechanical nociception / MGI
- decreased vertical activity / MGI
- abnormal dental pulp cavity morphology / MGI
- coarse hair / MGI
- increased growth rate / MGI
- increased insulin sensitivity / MGI
- abnormal bone mineralization / MGI
- increased circulating parathyroid hormone level / MGI
- decreased circulating alkaline phosphatase level / MGI
- arthritis / MGI
- abnormal bone healing / MGI
- no phenotypic analysis / MGI
- decreased skin tensile strength / MGI
- decreased tendon stiffness / MGI
- short femur / MGI
- decreased susceptibility to age related obesity / MGI
- aneurysm / MGI
- osteoarthritis / MGI
- abnormal long bone morphology / MGI
- abnormal compact bone morphology / MGI
- abnormal forelimb zeugopod morphology / MGI
- increased hepatocyte proliferation / MGI
- abnormal hormone level / MGI
- increased lean body mass / MGI
- decreased thermal nociceptive threshold / MGI
- decreased bone mass / MGI
- aortic dissection / MGI
- abnormal chest morphology / MGI
- abnormal pubis morphology / MGI
- abnormal ischium morphology / MGI
- abnormal pelvic girdle bone morphology / MGI
- thin ribs / MGI
- rib fractures / MGI
- decreased length of long bones / MGI
- abnormal vertebral column morphology / MGI
- short vertebral body / MGI
- increased susceptibility to age-related hearing loss / MGI
- abnormal osteoblast morphology / MGI
- increased osteoblast cell number / MGI
- decreased bone strength / MGI
- increased bone resorption / MGI
- abnormal osteoblast physiology / MGI
- liver hyperplasia / MGI
- decreased susceptibility to injury / MGI
- ocular hypertension / MGI
- improved glucose tolerance / MGI
- abnormal humerus morphology / MGI
- abnormal enzyme/coenzyme level / MGI
- abnormal myocardium layer morphology / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- digestive/alimentary phenotype / MGI
- reproductive system phenotype / MGI
- skeleton phenotype / MGI
- vision/eye phenotype / MGI
- decreased percent body fat/body weight / MGI
- abnormal skeleton morphology / MGI
- decreased circulating glucose level / MGI
- decreased ventricle muscle contractility / MGI
- decreased susceptibility to diet-induced obesity / MGI
- spinal hemorrhage / MGI
- abnormal heart septum morphology / MGI
- impaired hearing / MGI
- decreased diameter of femur / MGI
- abnormal myometrium morphology / MGI
- abnormal osteoblast differentiation / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- abnormal osteocyte morphology / MGI
- fused carpal bones / MGI
- delayed female fertility / MGI
- small pancreatic islets / MGI
- decreased trabecular bone thickness / MGI
- abnormal endoplasmic reticulum morphology / MGI
- abnormal aorta elastic tissue morphology / MGI
- abnormal aorta tunica adventitia morphology / MGI
- decreased total body fat amount / MGI
- abnormal thoracic cage shape / MGI
- decreased bone mineral content / MGI
- abnormal heart electrocardiography waveform feature / MGI
- myocardial hypertrophy / MGI
- increased QRS amplitude / MGI
- abnormal bone trabecula morphology / MGI
- decreased bone trabecula number / MGI
- decreased bone volume / MGI
- decreased trabecular bone volume / MGI
- pulmonary alveolar hemorrhage / MGI
- abnormal compact bone lamellar structure / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- abnormal bone collagen fibril morphology / MGI
- abnormal tendon collagen fibril morphology / MGI
- decreased neuronal stem cell self-renewal / MGI
- thin body / MGI
- abnormal extracellular matrix morphology / MGI
- osteophytes / MGI
- increased bone trabecular spacing / MGI
- decreased bone trabecular spacing / MGI
- decreased bone ossification / MGI
- decreased bone mineralization / MGI
- decreased collagen level / MGI
- broad face / MGI
- thick neurocranium / MGI
- thin neurocranium / MGI
- increased osteoblast apoptosis / MGI
- abnormal dentin mineralization / MGI
- increased osteocyte apoptosis / MGI
- abnormal osteocyte lacuna morphology / MGI
- joint contracture / MGI
- atlanto-occipital joint dislocation / MGI
- abnormal olecranon morphology / MGI
B6;129S4-Col1a1tm1(tetO-Vegfc)Mmul/Biat
Status | Available to order |
EMMA ID | EM:07833 |
International strain name | B6;129S4-Col1a1tm1(tetO-Vegfc)Mmul/Biat |
Alternative name | B6N;129P2-Col1a1tm1(tetO-VEGFC)Biat |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Col1a1tm1(tetO-Vegfc)Mmul |
Gene/Transgene symbol | Col1a1 |
Information from provider
Provider | Mathias Mueller |
Provider affiliation | Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna |
Genetic information | KH2 ES cells were targeted with a construct harbouring the tetO followed by the Vegfc cDNA into the Col1a1 locus (downstream of the polyA). |
Phenotypic information | Homozygous:There is no obvious phenotype.Heterozygous:Mice were kept so far heterozygous. |
Breeding history | ES cells were injected into blastocysts and resulting chimeras were crossed to C57BL/6N females. Transgenic offspring were mated with wild-type offspring (non siblings). |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Ehlers-Danlos/osteogenesis imperfecta syndrome / Orphanet_230857
- Osteogenesis imperfecta type 3 / Orphanet_216812
- Arthrochalasia Ehlers-Danlos syndrome / Orphanet_1899
- Classical Ehlers-Danlos syndrome / Orphanet_287
- Osteogenesis imperfecta type 2 / Orphanet_216804
- Osteogenesis imperfecta type 4 / Orphanet_216820
- Caffey disease / Orphanet_1310
- High bone mass osteogenesis imperfecta / Orphanet_314029
- Osteogenesis imperfecta type 1 / Orphanet_216796
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).