C57BL/6NTac-Fkbp10^{tm2a(EUCOMM)Wtsi}/IcsOrl

Status	Available to order
EMMA ID	EM:07823
International strain name	C57BL/6NTac-Fkbp10^{tm2a(EUCOMM)Wtsi}/IcsOrl
Alternative name	EPD0142_1_A09
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Fkbp10^{tm2a(EUCOMM)Wtsi}
Gene/Transgene symbol	Fkbp10
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone EPD0142_1_A09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6NTac, wild-type C57BL/6NTac
Stage of embryos	8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Bruck syndrome / Orphanet_2771
Kuskokwim syndrome / Orphanet_1149
Osteogenesis imperfecta type 3 / Orphanet_216812
Osteogenesis imperfecta type 4 / Orphanet_216820

IMPC phenotypes (allele matching)

abnormal tail movements / IMPC
increased startle reflex / IMPC
abnormal bone mineralization / IMPC
decreased prepulse inhibition / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

increased startle reflex / IMPC
abnormal tail movements / IMPC
abnormal bone mineralization / IMPC
preweaning lethality, complete penetrance / IMPC
decreased prepulse inhibition / IMPC

MGI phenotypes (allele matching)

abnormal cell morphology / MGI
abnormal craniofacial morphology / MGI
abnormal forelimb morphology / MGI
abnormal embryonic tissue morphology / MGI
abnormal endoplasmic reticulum morphology / MGI
prenatal growth retardation / MGI
decreased aorta wall thickness / MGI
neonatal lethality, complete penetrance / MGI
abnormal bone collagen fibril morphology / MGI
abnormal extracellular matrix morphology / MGI

MGI phenotypes (gene matching)

abnormal cell morphology / MGI
abnormal craniofacial morphology / MGI
abnormal forelimb morphology / MGI
abnormal embryonic tissue morphology / MGI
abnormal endoplasmic reticulum morphology / MGI
prenatal growth retardation / MGI
decreased aorta wall thickness / MGI
neonatal lethality, complete penetrance / MGI
abnormal bone collagen fibril morphology / MGI
abnormal extracellular matrix morphology / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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