C57BL/6NTac-Ift122^{tm1a(EUCOMM)Wtsi}/IcsOrl

Status	Available to order
EMMA ID	EM:07822
International strain name	C57BL/6NTac-Ift122^{tm1a(EUCOMM)Wtsi}/IcsOrl
Alternative name	EPD0155_2_E05
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Ift122^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Ift122
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone EPD0155_2_E05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6NTac, wild-type C57BL/6NTac
Stage of embryos	8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Cranioectodermal dysplasia / Orphanet_1515

IMPC phenotypes (allele matching)

decreased locomotor activity / IMPC
increased mean corpuscular volume / IMPC
abnormal behavior / IMPC
increased circulating aspartate transaminase level / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

increased mean corpuscular volume / IMPC
decreased locomotor activity / IMPC
preweaning lethality, complete penetrance / IMPC
abnormal behavior / IMPC
increased circulating aspartate transaminase level / IMPC

MGI phenotypes (gene matching)

enlarged heart / MGI
abnormal cell morphology / MGI
abnormal head morphology / MGI
polydactyly / MGI
exencephaly / MGI
open neural tube / MGI
abnormal spinal cord morphology / MGI
abnormal eye development / MGI
abnormal left-right axis patterning / MGI
hemorrhage / MGI
abnormal eye morphology / MGI
abnormal neural tube morphology / MGI
situs inversus / MGI
abnormal abdominal wall morphology / MGI
abnormal cell cycle checkpoint function / MGI
polysyndactyly / MGI
abnormal spinal cord interneuron morphology / MGI
abnormal motile primary cilium morphology / MGI
absent embryonic cilia / MGI
delayed embryo turning / MGI
abnormal direction of heart looping / MGI
increased motor neuron number / MGI
ectrodactyly / MGI
abnormal limb development / MGI
decreased physiological sensitivity to xenobiotic / MGI
decreased sensitivity to induced cell death / MGI
preaxial polydactyly / MGI
abnormal pharyngeal arch development / MGI
right-sided stomach / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
decreased embryonic cilium length / MGI
delayed limb development / MGI
elongated neck / MGI
enlarged pharyngeal arch / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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