C57BL/6N-Flnbtm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:07802
International strain nameC57BL/6N-Flnbtm1a(KOMP)Wtsi/H
Alternative nameEPD0585_1_F09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFlnbtm1a(KOMP)Wtsi
Gene/Transgene symbolFlnb
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0585_1_F09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased bone mineral density / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased bone mineral content / IMPC
  • decreased lean body mass / IMPC
  • increased total body fat amount / IMPC
  • decreased red blood cell distribution width / IMPC
  • increased circulating serum albumin level / IMPC
  • decreased neutrophil cell number / IMPC
MGI phenotypes (gene matching)
  • delayed bone ossification / MGI
  • decreased bone mineral density / MGI
  • kyphoscoliosis / MGI
  • abnormal neurocranium morphology / MGI
  • abnormal parietal bone morphology / MGI
  • decreased compact bone thickness / MGI
  • rib fusion / MGI
  • abnormal sternum morphology / MGI
  • kyphosis / MGI
  • scoliosis / MGI
  • lordosis / MGI
  • abnormal chondrocyte morphology / MGI
  • abnormal angiogenesis / MGI
  • short limbs / MGI
  • abnormal radius morphology / MGI
  • decreased body height / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal gait / MGI
  • dehydration / MGI
  • abnormal posture / MGI
  • postnatal growth retardation / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal skeleton development / MGI
  • abnormal limb bone morphology / MGI
  • brachyphalangia / MGI
  • short tibia / MGI
  • abnormal bone mineralization / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • decreased rib number / MGI
  • increased width of hypertrophic chondrocyte zone / MGI
  • decreased width of hypertrophic chondrocyte zone / MGI
  • abnormal artery development / MGI
  • delayed endochondral bone ossification / MGI
  • delayed intramembranous bone ossification / MGI
  • abnormal cell adhesion / MGI
  • abnormal long bone epiphyseal plate proliferative zone / MGI
  • abnormal sternebra morphology / MGI
  • short radius / MGI
  • vertebral fusion / MGI
  • cervical vertebral fusion / MGI
  • thoracic vertebral fusion / MGI
  • abnormal thoracic cage morphology / MGI
  • thin ribs / MGI
  • absent intervertebral disk / MGI
  • decreased length of long bones / MGI
  • abnormal vertebral column morphology / MGI
  • abnormal brain vasculature morphology / MGI
  • abnormal ulna morphology / MGI
  • abnormal occipital bone morphology / MGI
  • abnormal viscerocranium morphology / MGI
  • abnormal patella morphology / MGI
  • tachypnea / MGI
  • abnormal cell physiology / MGI
  • abnormal perichondrium morphology / MGI
  • decreased long bone epiphyseal plate size / MGI
  • abnormal hyaline cartilage morphology / MGI
  • decreased diameter of radius / MGI
  • decreased diameter of ulna / MGI
  • abnormal bone ossification / MGI
  • slow postnatal weight gain / MGI
  • decreased survivor rate / MGI
  • fused carpal bones / MGI
  • abnormal chondrocyte physiology / MGI
  • small thoracic cage / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • decreased fibroblast cell migration / MGI
  • abnormal extracellular matrix morphology / MGI
  • decreased bone ossification / MGI
  • decreased bone mineralization / MGI
  • abnormal middle cerebral artery morphology / MGI
  • joint laxity / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Genotyping protocol

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