C57BL/6N-Usp14tm2a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:07787
International strain nameC57BL/6N-Usp14tm2a(EUCOMM)Wtsi/H
Alternative nameEPD0582_2_G09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolUsp14tm2a(EUCOMM)Wtsi
Gene/Transgene symbolUsp14
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0582_2_G09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • muscle spasm / MGI
  • tremors / MGI
  • weakness / MGI
  • muscle weakness / MGI
  • muscle degeneration / MGI
  • paralysis / MGI
  • decreased corpus callosum size / MGI
  • abnormal dentate gyrus morphology / MGI
  • abnormal hindbrain morphology / MGI
  • abnormal pons morphology / MGI
  • small cerebellum / MGI
  • Purkinje cell degeneration / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • abnormal spinal nerve morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • reduced long term potentiation / MGI
  • limb grasping / MGI
  • postnatal growth retardation / MGI
  • impaired synaptic plasticity / MGI
  • male infertility / MGI
  • female infertility / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • abnormal brain commissure morphology / MGI
  • muscular atrophy / MGI
  • abnormal mechanical nociception / MGI
  • increased synaptic depression / MGI
  • decreased paired-pulse facilitation / MGI
  • decreased post-tetanic potentiation / MGI
  • abnormal lumbar vertebrae morphology / MGI
  • increased neuron apoptosis / MGI
  • axonal dystrophy / MGI
  • priapism / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system physiology / MGI
  • abnormal synaptic transmission / MGI
  • abnormal cerebellar granule cell morphology / MGI
  • abnormal limbic system morphology / MGI
  • short lumbar vertebrae / MGI
  • abnormal miniature endplate potential / MGI
  • abnormal brainstem morphology / MGI
  • muscle phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal neurotransmitter secretion / MGI
  • abnormal spinal cord white matter morphology / MGI
  • decreased hippocampal commissure size / MGI
  • abnormal cingulum morphology / MGI
  • small hippocampus / MGI
  • paraparesis / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • perinatal lethality, complete penetrance / MGI
  • decreased midbrain size / MGI
  • abnormal pontine nuclei morphology / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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