C57BL/6N-Shhtm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:07782
International strain nameC57BL/6N-Shhtm1a(EUCOMM)Wtsi/H
Alternative nameEPD0339_3_A12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolShhtm1a(EUCOMM)Wtsi
Gene/Transgene symbolShh
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0339_3_A12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased total body fat amount / IMPC
  • decreased lean body mass / IMPC
  • limb grasping / IMPC
  • decreased bone mineral content / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased startle reflex / IMPC
  • impaired glucose tolerance / IMPC
  • increased circulating HDL cholesterol level / IMPC
MGI phenotypes (gene matching)
  • absent scala media / MGI
  • absent endolymphatic duct / MGI
  • abnormal neurocranium morphology / MGI
  • abnormal frontal bone morphology / MGI
  • abnormal vertebrae morphology / MGI
  • absent vertebrae / MGI
  • abnormal rib morphology / MGI
  • abnormal cartilage morphology / MGI
  • abnormal cartilage development / MGI
  • abnormal heart morphology / MGI
  • abnormal hair follicle morphology / MGI
  • absent hair follicles / MGI
  • abnormal hair follicle orientation / MGI
  • absent hair follicle inner root sheath / MGI
  • alopecia / MGI
  • abnormal craniofacial morphology / MGI
  • microcephaly / MGI
  • abnormal cranium morphology / MGI
  • absent mouth / MGI
  • abnormal maxilla morphology / MGI
  • abnormal digestive system morphology / MGI
  • abnormal esophagus morphology / MGI
  • abnormal stomach glandular epithelium morphology / MGI
  • abnormal foregut morphology / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal colon morphology / MGI
  • abnormal small intestine morphology / MGI
  • short limbs / MGI
  • absent forelimb / MGI
  • abnormal hindlimb morphology / MGI
  • absent hindlimb / MGI
  • adactyly / MGI
  • polydactyly / MGI
  • syndactyly / MGI
  • oligodactyly / MGI
  • abnormal autopod morphology / MGI
  • abnormal liver development / MGI
  • abnormal smooth muscle morphology / MGI
  • decreased brain size / MGI
  • abnormal forebrain morphology / MGI
  • abnormal telencephalon morphology / MGI
  • cerebellum hypoplasia / MGI
  • abnormal cerebellum external granule cell layer morphology / MGI
  • absent floor plate / MGI
  • absent notochord / MGI
  • abnormal motor neuron morphology / MGI
  • decreased motor neuron number / MGI
  • decreased spinal cord size / MGI
  • abnormal enteric neuron morphology / MGI
  • abnormal lung morphology / MGI
  • abnormal lung development / MGI
  • pulmonary hypoplasia / MGI
  • thick epidermis / MGI
  • epidermal hyperplasia / MGI
  • abnormal dermal layer morphology / MGI
  • decreased body weight / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal vasculogenesis / MGI
  • abnormal embryo development / MGI
  • abnormal somite shape / MGI
  • abnormal embryo size / MGI
  • decreased embryo size / MGI
  • abnormal dorsal-ventral axis patterning / MGI
  • perinatal lethality / MGI
  • abnormal eye morphology / MGI
  • abnormal ear morphology / MGI
  • abnormal limb morphology / MGI
  • abnormal axial skeleton morphology / MGI
  • abnormal limb bone morphology / MGI
  • abnormal craniofacial bone morphology / MGI
  • abnormal cardiovascular system morphology / MGI
  • abnormal respiratory system morphology / MGI
  • abnormal kidney morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased brain weight / MGI
  • abnormal pharynx morphology / MGI
  • abnormal bronchus morphology / MGI
  • abnormal tracheal smooth muscle morphology / MGI
  • brachyphalangia / MGI
  • brachydactyly / MGI
  • small stomach / MGI
  • absent tibia / MGI
  • small olfactory bulb / MGI
  • short tibia / MGI
  • short fibula / MGI
  • abnormal posterior semicircular canal morphology / MGI
  • absent cartilage / MGI
  • abnormal joint morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal superior semicircular canal morphology / MGI
  • abnormal tracheal cartilage morphology / MGI
  • anal atresia / MGI
  • absent lateral semicircular canal / MGI
  • fused joints / MGI
  • abnormal duodenum morphology / MGI
  • abnormal digestive organ placement / MGI
  • tracheoesophageal fistula / MGI
  • decreased rib number / MGI
  • abnormal optic vesicle formation / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system morphology / MGI
  • abnormal hair follicle development / MGI
  • abnormal long bone morphology / MGI
  • abnormal submandibular gland morphology / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal forelimb zeugopod morphology / MGI
  • abnormal hindlimb zeugopod morphology / MGI
  • abnormal heart left atrium morphology / MGI
  • embryonic growth retardation / MGI
  • abnormal lung vasculature morphology / MGI
  • abnormal spinal cord interneuron morphology / MGI
  • abnormal prenatal growth/weight/body size / MGI
  • decreased fetal size / MGI
  • fetal growth retardation / MGI
  • abnormal optic stalk morphology / MGI
  • abnormal optic cup morphology / MGI
  • abnormal embryonic/fetal subventricular zone morphology / MGI
  • abnormal postnatal subventricular zone morphology / MGI
  • absent vestibulocochlear ganglion / MGI
  • absent vestibular saccule / MGI
  • bowed tibia / MGI
  • absent utricle / MGI
  • bowed fibula / MGI
  • abnormal respiratory conducting tube morphology / MGI
  • occipital bone foramen / MGI
  • absent tracheal cartilage rings / MGI
  • cervical vertebral fusion / MGI
  • short metacarpal bones / MGI
  • notochord degeneration / MGI
  • abnormal gallbladder morphology / MGI
  • holoprosencephaly / MGI
  • cyclopia / MGI
  • gastric metaplasia / MGI
  • abnormal humerus morphology / MGI
  • abnormal phalanx morphology / MGI
  • limbs/digits/tail phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • embryo phenotype / MGI
  • behavior/neurological phenotype / MGI
  • absent fibula / MGI
  • stomach epithelial hyperplasia / MGI
  • abnormal skeleton morphology / MGI
  • abnormal vascular smooth muscle morphology / MGI
  • abnormal cell physiology / MGI
  • abnormal otic vesicle development / MGI
  • increased apoptosis / MGI
  • annular pancreas / MGI
  • abnormal limb development / MGI
  • abnormal nasal pit morphology / MGI
  • slow postnatal weight gain / MGI
  • hemimelia / MGI
  • absent external male genitalia / MGI
  • absent external female genitalia / MGI
  • abnormal cystic duct morphology / MGI
  • abnormal dermis papillary layer morphology / MGI
  • acephaly / MGI
  • decreased keratinocyte proliferation / MGI
  • abnormal atrium myocardium morphology / MGI
  • absent pulmonary vein / MGI
  • fusion of atlas and odontoid process / MGI
  • abnormal lung saccule morphology / MGI
  • impaired lung lobe morphogenesis / MGI
  • abnormal branching involved in lung morphogenesis / MGI
  • impaired branching involved in bronchus morphogenesis / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • decreased somite size / MGI
  • decreased midbrain size / MGI
  • absent diencephalon / MGI
  • decreased chondrocyte proliferation / MGI
  • abnormal chondrocyte differentiation / MGI
  • abnormal gallbladder size / MGI
  • thin interparietal bone / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).