C57BL/6NTac-Aldh3a2tm1a(EUCOMM)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:07734
International strain nameC57BL/6NTac-Aldh3a2tm1a(EUCOMM)Wtsi/IcsOrl
Alternative nameEPD0060_2_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAldh3a2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolAldh3a2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0060_2_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased locomotor activity / IMPC
  • increased startle reflex / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal behavior / IMPC
  • decreased prepulse inhibition / IMPC
IMPC phenotypes (gene matching)
  • decreased prepulse inhibition / IMPC
  • increased startle reflex / IMPC
  • abnormal behavior / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased locomotor activity / IMPC
MGI phenotypes (gene matching)
  • abnormal epidermis stratum basale morphology / MGI
  • abnormal epidermis stratum spinosum morphology / MGI
  • abnormal epidermis stratum granulosum morphology / MGI
  • abnormal keratinocyte physiology / MGI
  • oxidative stress / MGI
  • abnormal phospholipid level / MGI
  • delayed skin barrier formation / MGI
  • increased keratinocyte proliferation / MGI
  • increased food intake / MGI
  • abnormal lipid metabolism / MGI
  • decreased aldehyde dehydrogenase activity / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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