C57BL/6NTac-Rc3h1tm1a(EUCOMM)Hmgu/IcsOrl

Status

Available to order

EMMA IDEM:07733
International strain nameC57BL/6NTac-Rc3h1tm1a(EUCOMM)Hmgu/IcsOrl
Alternative nameHEPD0546_1_F01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolRc3h1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolRc3h1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0546_1_F01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6N Tac, wild-type C57BL/6NTac
Stage of embryos8-cell

Disease and phenotype information

MGI phenotypes (gene matching)
  • crypts of Lieberkuhn abscesses / MGI
  • intestinal ulcer / MGI
  • lymphoid hyperplasia / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • abnormal thymus development / MGI
  • abnormal lung development / MGI
  • decreased body weight / MGI
  • anemia / MGI
  • hepatic necrosis / MGI
  • postnatal growth retardation / MGI
  • increased activated T cell number / MGI
  • intestinal inflammation / MGI
  • liver inflammation / MGI
  • increased T cell derived lymphoma incidence / MGI
  • abnormal T cell differentiation / MGI
  • abnormal lymph node morphology / MGI
  • abnormal effector T cell morphology / MGI
  • increased IgG level / MGI
  • granulomatous inflammation / MGI
  • glomerulonephritis / MGI
  • colitis / MGI
  • no phenotypic analysis / MGI
  • curly tail / MGI
  • thrombocytopenia / MGI
  • small intestinal inflammation / MGI
  • abnormal neural tube closure / MGI
  • abnormal vertebral column morphology / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • abnormal small intestine crypts of Lieberkuhn morphology / MGI
  • increased spleen weight / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • abnormal small intestinal villus morphology / MGI
  • abnormal lymph node germinal center morphology / MGI
  • increased circulating tumor necrosis factor level / MGI
  • abnormal intraepithelial T cell number / MGI
  • cecum inflammation / MGI
  • ileum inflammation / MGI
  • increased T follicular helper cell number / MGI
  • abnormal T follicular helper cell physiology / MGI
  • primary atelectasis / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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