C57BL/6NTac-Clk1tm1a(EUCOMM)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:07704
International strain nameC57BL/6NTac-Clk1tm1a(EUCOMM)Wtsi/IcsOrl
Alternative nameEPD0065_2_E04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolClk1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolClk1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0065_2_E04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac, wild-type C57BL/6NTac
Stage of embryos8-cell

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating calcium level / IMPC
  • decreased granulocyte number / IMPC
  • tremors / IMPC
  • abnormal retina morphology / IMPC
  • increased startle reflex / IMPC
  • increased circulating phosphate level / IMPC
  • abnormal response to tactile stimuli / IMPC
  • decreased circulating serum albumin level / IMPC
  • thrombocytosis / IMPC
  • increased circulating creatinine level / IMPC
  • decreased NK cell number / IMPC
  • increased IgG2b level / IMPC
  • increased bone mineral content / IMPC
IMPC phenotypes (gene matching)
  • thrombocytosis / IMPC
  • increased startle reflex / IMPC
  • abnormal retina morphology / IMPC
  • abnormal response to tactile stimuli / IMPC
  • decreased granulocyte number / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating calcium level / IMPC
  • increased IgG2b level / IMPC
  • tremors / IMPC
  • increased bone mineral content / IMPC
  • increased circulating phosphate level / IMPC
  • increased circulating creatinine level / IMPC
  • decreased NK cell number / IMPC
MGI phenotypes (allele matching)
  • decreased body weight / MGI
MGI phenotypes (gene matching)
  • decreased body weight / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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