C57BL/6NTac-Ngfrtm1a(EUCOMM)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:07691
International strain nameC57BL/6NTac-Ngfrtm1a(EUCOMM)Wtsi/IcsOrl
Alternative nameEPD0059_4_D03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNgfrtm1a(EUCOMM)Wtsi
Gene/Transgene symbolNgfr
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0059_4_D03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac, wild-type C57BL/6NTac
Stage of embryos8-cell

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal retina morphology / IMPC
  • increased startle reflex / IMPC
  • abnormal eye morphology / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal digit morphology / IMPC
  • abnormal eye morphology / IMPC
  • increased startle reflex / IMPC
  • limb grasping / IMPC
  • abnormal gait / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased thigmotaxis / IMPC
  • abnormal retina morphology / IMPC
  • increased circulating phosphate level / IMPC
  • tremors / IMPC
  • abnormal behavior / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • decreased locomotor activity / IMPC
MGI phenotypes (gene matching)
  • organ of Corti degeneration / MGI
  • absent hair follicles / MGI
  • abnormal mouth morphology / MGI
  • ulcerated paws / MGI
  • abnormal tongue epithelium morphology / MGI
  • abnormal superior colliculus morphology / MGI
  • decreased motor neuron number / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • abnormal sensory neuron innervation pattern / MGI
  • small L4 dorsal root ganglion / MGI
  • abnormal L5 dorsal root ganglion morphology / MGI
  • abnormal cholinergic neuron morphology / MGI
  • abnormal innervation pattern to muscle / MGI
  • abnormal trigeminal ganglion morphology / MGI
  • decreased Schwann cell number / MGI
  • decreased body size / MGI
  • ataxia / MGI
  • abnormal gait / MGI
  • abnormal spatial learning / MGI
  • abnormal posture / MGI
  • limb grasping / MGI
  • abnormal blood vessel morphology / MGI
  • postnatal growth retardation / MGI
  • hemorrhage / MGI
  • abnormal sensory capabilities/reflexes/nociception / MGI
  • abnormal tooth morphology / MGI
  • abnormal muscle morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased airway responsiveness / MGI
  • abnormal sciatic nerve morphology / MGI
  • abnormal molar morphology / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal neuron morphology / MGI
  • abnormal axon guidance / MGI
  • decreased myocardial infarction size / MGI
  • extremity edema / MGI
  • abnormal neuron apoptosis / MGI
  • decreased neuron apoptosis / MGI
  • abnormal axon extension / MGI
  • abnormal molar crown morphology / MGI
  • dilated dorsal aorta / MGI
  • abnormal peripheral nervous system regeneration / MGI
  • abnormal proprioceptive neuron morphology / MGI
  • cochlear hair cell degeneration / MGI
  • sensorineural hearing loss / MGI
  • increased susceptibility to age-related hearing loss / MGI
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • abnormal vascular wound healing / MGI
  • abnormal eye physiology / MGI
  • renal/urinary system phenotype / MGI
  • increased retinal photoreceptor cell number / MGI
  • abnormal circumvallate papillae morphology / MGI
  • abnormal gustatory papillae taste bud morphology / MGI
  • abnormal retinal ganglion cell morphology / MGI
  • abnormal Kupffer cell morphology / MGI
  • decreased muscle spindle number / MGI
  • abnormal tumor necrosis factor level / MGI
  • increased neuron number / MGI
  • abnormal axon pruning / MGI
  • abnormal neuron differentiation / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • increased or absent threshold for auditory brainstem response / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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