STOCK Fgl1^{tm1a(EUCOMM)Hmgu}/IcsOrl

Status	Available to order
EMMA ID	EM:07684
International strain name	STOCK Fgl1^{tm1a(EUCOMM)Hmgu}/IcsOrl
Alternative name	HEPD0540_3_F06
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Fgl1^{tm1a(EUCOMM)Hmgu}
Gene/Transgene symbol	Fgl1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0540_3_F06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6NTac, wild-type C57BL/6NTac
Stage of embryos	8-cell

Disease and phenotype information

IMPC phenotypes (allele matching)

increased circulating HDL cholesterol level / IMPC
abnormal bone mineralization / IMPC
abnormal bone structure / IMPC
increased lean body mass / IMPC
increased circulating cholesterol level / IMPC
increased circulating glucose level / IMPC
increased total body fat amount / IMPC
increased bone mineral content / IMPC

IMPC phenotypes (gene matching)

increased circulating HDL cholesterol level / IMPC
abnormal bone mineralization / IMPC
increased circulating glucose level / IMPC
increased lean body mass / IMPC
increased total body fat amount / IMPC
increased bone mineral content / IMPC
abnormal bone structure / IMPC
increased circulating cholesterol level / IMPC

MGI phenotypes (gene matching)

increased white adipose tissue amount / MGI
decreased circulating HDL cholesterol level / MGI
increased body length / MGI
increased body weight / MGI
hyperglycemia / MGI
hepatic steatosis / MGI
decreased circulating free fatty acid level / MGI
abnormal gluconeogenesis / MGI
abnormal liver weight / MGI
decreased circulating cholesterol level / MGI
impaired glucose tolerance / MGI
homeostasis/metabolism phenotype / MGI
behavior/neurological phenotype / MGI
abnormal brown fat cell morphology / MGI
increased white fat cell size / MGI
increased brown fat cell lipid droplet size / MGI
decreased white fat cell number / MGI
increased liver triglyceride level / MGI
decreased respiratory quotient / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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