C57BL/6NTac-Tnfrsf1b^{tm1a(EUCOMM)Wtsi}/IcsOrl

Status	Available to order
EMMA ID	EM:07654
International strain name	C57BL/6NTac-Tnfrsf1b^{tm1a(EUCOMM)Wtsi}/IcsOrl
Alternative name	EPD0155_1_B07
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Tnfrsf1b^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Tnfrsf1b
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone EPD0155_1_B07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6N Tac, wild-type C57BL/6N Tac
Stage of embryos	8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Sézary syndrome / Orphanet_3162
Classic mycosis fungoides / Orphanet_2584

IMPC phenotypes (allele matching)

decreased locomotor activity / IMPC
increased B cell number / IMPC
decreased T cell number / IMPC
increased circulating total protein level / IMPC
decreased prepulse inhibition / IMPC

IMPC phenotypes (gene matching)

decreased T cell number / IMPC
increased B cell number / IMPC
decreased locomotor activity / IMPC
decreased prepulse inhibition / IMPC
increased circulating total protein level / IMPC

MGI phenotypes (gene matching)

abnormal sleep pattern / MGI
abnormal immune system physiology / MGI
increased inflammatory response / MGI
lung inflammation / MGI
increased skin papilloma incidence / MGI
no abnormal phenotype detected / MGI
abnormal blood gas level / MGI
abnormal lung compliance / MGI
decreased susceptibility to bacterial infection / MGI
increased susceptibility to bacterial infection / MGI
decreased systemic arterial blood pressure / MGI
abnormal glutamate-mediated receptor currents / MGI
increased susceptibility to experimental autoimmune encephalomyelitis / MGI
decreased susceptibility to autoimmune diabetes / MGI
increased susceptibility to parasitic infection / MGI
decreased T cell proliferation / MGI
homeostasis/metabolism phenotype / MGI
respiratory system phenotype / MGI
skeleton phenotype / MGI
periinsulitis / MGI
increased circulating tumor necrosis factor level / MGI
decreased interferon-gamma secretion / MGI
decreased interleukin-2 secretion / MGI
microgliosis / MGI
decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
impaired central nervous system regeneration / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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