IMPC phenotypes (gene matching)
C57BL/6NTac-Raf1tm1a(EUCOMM)Wtsi/IcsOrl
| Status | Available to order |
| EMMA ID | EM:07652 |
| International strain name | C57BL/6NTac-Raf1tm1a(EUCOMM)Wtsi/IcsOrl |
| Alternative name | EPD0065_4_B07 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Raf1tm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Raf1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
|
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0065_4_B07. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6N Tac, wild-type C57BL/6N Tac |
| Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Noonan syndrome / Orphanet_648
- Noonan syndrome with multiple lentigines / Orphanet_500
- Familial isolated dilated cardiomyopathy / Orphanet_154
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- increased monocyte cell number / MGI
- enlarged heart / MGI
- distended pericardium / MGI
- decreased cell proliferation / MGI
- small hair follicles / MGI
- underdeveloped hair follicles / MGI
- ruffled hair / MGI
- increased cranium width / MGI
- flattened snout / MGI
- liver hypoplasia / MGI
- small liver / MGI
- pale liver / MGI
- abnormal hepatocyte morphology / MGI
- enlarged spleen / MGI
- tremors / MGI
- abnormal epidermal layer morphology / MGI
- thin epidermis / MGI
- abnormal epidermis stratum corneum morphology / MGI
- abnormal dermal layer morphology / MGI
- thin dermal layer / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ocular hypertelorism / MGI
- eyelids open at birth / MGI
- abnormal retina morphology / MGI
- hunched posture / MGI
- abnormal cardiovascular system physiology / MGI
- anemia / MGI
- abnormal vasculogenesis / MGI
- cardiac hypertrophy / MGI
- abnormal apoptosis / MGI
- abnormal somite development / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- abnormal placenta labyrinth morphology / MGI
- absent vitelline blood vessels / MGI
- embryonic growth arrest / MGI
- hemorrhage / MGI
- respiratory failure / MGI
- prenatal lethality / MGI
- premature death / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal pulmonary alveolus morphology / MGI
- dilated cardiomyopathy / MGI
- increased heart weight / MGI
- thick ventricular wall / MGI
- no phenotypic analysis / MGI
- cardiac fibrosis / MGI
- increased cardiac output / MGI
- small lung / MGI
- pallor / MGI
- abnormal facial morphology / MGI
- increased left ventricle systolic pressure / MGI
- abnormal heart left ventricle morphology / MGI
- embryonic growth retardation / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- small placenta / MGI
- increased response of heart to induced stress / MGI
- enlarged myocardial fiber / MGI
- decreased placenta weight / MGI
- decreased cardiac muscle contractility / MGI
- cardiovascular system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased cardiac muscle contractility / MGI
- cardiac interstitial fibrosis / MGI
- increased apoptosis / MGI
- embryonic lethality during organogenesis / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased cranium height / MGI
- decreased cranium width / MGI
- enlarged heart right atrium / MGI
- increased heart ventricle size / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- increased sensitivity to induced cell death / MGI
- decreased sensitivity to induced cell death / MGI
- abnormal liver sinusoid morphology / MGI
- decreased embryo weight / MGI
- decreased fetal weight / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal cranium size / MGI
- increased heart left ventricle size / MGI
- thick interventricular septum / MGI
- abnormal heart left ventricle pressure / MGI
- neonatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI
- increased cardiac stroke volume / MGI
- decreased spongiotrophoblast size / MGI
- increased hepatoblast apoptosis / MGI
- increased fibroblast apoptosis / MGI
- increased embryonic tissue cell apoptosis / MGI