C57BL/6NTac-Thratm1a(EUCOMM)Wtsi/Ics

Status

Available to order

EMMA IDEM:07613
Citation informationRRID:IMSR_EM:07613 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Thratm1a(EUCOMM)Wtsi/Ics
Alternative nameEPD0204_5_F02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolThratm1a(EUCOMM)Wtsi
Gene/Transgene symbolThra
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0204_5_F02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Resistance to thyroid hormone due to a mutation in thyroid hormone receptor alpha / Orphanet_566231
IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • increased vertical activity / IMPC
  • increased startle reflex / IMPC
  • improved glucose tolerance / IMPC
  • abnormal retina inner nuclear layer morphology / IMPC
  • decreased startle reflex / IMPC
  • increased circulating creatinine level / IMPC
  • decreased total retina thickness / IMPC
  • abnormal contextual conditioning behavior / IMPC
  • short tibia / IMPC
  • increased bone mineral content / IMPC
  • abnormal heart left ventricle morphology / IMPC
  • limb grasping / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased bone mineral density / IMPC
  • decreased body length / IMPC
  • decreased total body fat amount / IMPC
  • increased blood urea nitrogen level / IMPC
  • abnormal bone structure / IMPC
  • increased hematocrit / IMPC
  • decreased grip strength / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased exploration in new environment / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal long bone metaphysis morphology / MGI
  • decreased compact bone thickness / MGI
  • delayed hair appearance / MGI
  • abnormal enterocyte morphology / MGI
  • abnormal small intestine morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • short limbs / MGI
  • short tail / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal cerebellum external granule cell layer morphology / MGI
  • decreased body length / MGI
  • increased body weight / MGI
  • obese / MGI
  • decreased body weight / MGI
  • increased anxiety-related response / MGI
  • abnormal pup retrieval / MGI
  • abnormal object recognition memory / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal bone strength / MGI
  • abnormal postnatal growth / MGI
  • postnatal growth retardation / MGI
  • reduced fertility / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • abnormal glucose homeostasis / MGI
  • increased circulating insulin level / MGI
  • premature death / MGI
  • small heart / MGI
  • increased heart rate / MGI
  • increased glucagon secretion / MGI
  • increased circulating glucagon level / MGI
  • short tibia / MGI
  • abnormal thyroid physiology / MGI
  • increased insulin sensitivity / MGI
  • abnormal bone mineralization / MGI
  • abnormal joint morphology / MGI
  • abnormal bone remodeling / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • increased insulin secretion / MGI
  • prolonged QT interval / MGI
  • abnormal locomotor coordination / MGI
  • decreased liver weight / MGI
  • decreased width of hypertrophic chondrocyte zone / MGI
  • delayed endochondral bone ossification / MGI
  • delayed intramembranous bone ossification / MGI
  • abnormal intestinal goblet cell morphology / MGI
  • thyroid hypoplasia / MGI
  • increased activity of thyroid / MGI
  • decreased activity of thyroid / MGI
  • abnormal insulin secretion / MGI
  • oliguria / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal long bone epiphyseal plate proliferative zone / MGI
  • abnormal bone structure / MGI
  • abnormal compact bone morphology / MGI
  • abnormal defecation / MGI
  • abnormal hormone level / MGI
  • abnormal thyroid-stimulating hormone level / MGI
  • increased compact bone thickness / MGI
  • abnormal long bone diaphysis morphology / MGI
  • short ulna / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • decreased length of long bones / MGI
  • abnormal thyroid follicle morphology / MGI
  • decreased circulating insulin-like growth factor I level / MGI
  • decreased mean systemic arterial blood pressure / MGI
  • decreased osteoclast cell number / MGI
  • decreased bone resorption / MGI
  • increased circulating thyroid-stimulating hormone level / MGI
  • increased thyroid-stimulating hormone level / MGI
  • abnormal pancreatic islet morphology / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • decreased heart rate / MGI
  • hearing/vestibular/ear phenotype / MGI
  • behavior/neurological phenotype / MGI
  • skeleton phenotype / MGI
  • osteosclerosis / MGI
  • increased triiodothyronine level / MGI
  • increased circulating thyroxine level / MGI
  • decreased circulating thyroxine level / MGI
  • decreased circulating triiodothyronine level / MGI
  • increased circulating triiodothyronine level / MGI
  • increased body temperature / MGI
  • decreased body temperature / MGI
  • increased circulating glucose level / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • decreased ventricle muscle contractility / MGI
  • increased bone mass / MGI
  • increased circulating leptin level / MGI
  • increased long bone epiphyseal plate size / MGI
  • abnormal long bone epiphyseal ossification zone morphology / MGI
  • impaired lipolysis / MGI
  • increased diameter of long bones / MGI
  • abnormal enterocyte physiology / MGI
  • abnormal enterocyte proliferation / MGI
  • prolonged estrous cycle / MGI
  • small pancreatic islets / MGI
  • increased epididymal fat pad weight / MGI
  • increased trabecular bone thickness / MGI
  • abnormal chondrocyte physiology / MGI
  • increased total body fat amount / MGI
  • abnormal bone mineral content / MGI
  • increased bone mineral content / MGI
  • decreased bone mineral content / MGI
  • prolonged QRS complex duration / MGI
  • delayed cranial suture closure / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone volume / MGI
  • abnormal mitochondrial ATP synthesis coupled electron transport / MGI
  • increased compact bone volume / MGI
  • decreased compact bone area / MGI
  • decreased core body temperature / MGI
  • impaired adaptive thermogenesis / MGI
  • postnatal lethality, complete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • decreased food intake / MGI
  • decreased areal bone mineral density / MGI
  • decreased small intestine length / MGI
  • decreased small intestinal villus height / MGI
  • decreased cardiac cell glucose uptake / MGI
  • wide cranial sutures / MGI
  • large fontanelles / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).