IMPC phenotypes (gene matching)
B6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Orl
| Status | Available to order |
| EMMA ID | EM:00754 |
| Citation information | RRID:IMSR_EM:00754 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Orl |
| Alternative name | TetraKO - CD3- and MHC class I- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd3etm1Mal, B2mtm1Unc, H2-D1b-tm1Bpe, H2-K1b-tm1Bpe |
| Gene/Transgene symbol | Cd3e, B2m, H2-D1, H2-K1 |
Information from provider
| Provider | Antonio Freitas |
| Provider affiliation | Institut Pasteur |
| Genetic information | Inactivation of the Cd3epsilon gene. Inactivation of the b allele of both D and K loci of the MHC class I molecules. Inactivation of the beta-2 microglobulin gene. |
| Phenotypic information | Lack of T lymphocytes and MHC class I molecules. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous males, wild-type females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta / Orphanet_169160
MGI phenotypes (allele matching)
- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
- arrested T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal B cell morphology / MGI
- abnormal regulatory T cell physiology / MGI
- absent T cells / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- absent CD4-positive, alpha beta T cells / MGI
MGI phenotypes (gene matching)
- absent CD8-positive, alpha-beta T cells / MGI
- decreased IgG level / MGI
- decreased level of surface class I molecules / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
- increased IgM level / MGI
- insulitis / MGI
- abnormal lateral geniculate nucleus morphology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to parasitic infection / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal pancreatic beta cell morphology / MGI
- decreased circulating serum albumin level / MGI
- hemochromatosis / MGI
- abnormal T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased T-helper 1 cell number / MGI
- increased gamma-delta T cell number / MGI
- increased gamma-delta intraepithelial T cell number / MGI
- increased tumor necrosis factor secretion / MGI
- increased interleukin-3 secretion / MGI
- decreased interleukin-4 secretion / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- abnormal thymus morphology / MGI
- small thymus / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- seizures / MGI
- abnormal T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal double-positive T cell morphology / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal class switch recombination / MGI
- abnormal B cell morphology / MGI
- abnormal regulatory T cell physiology / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- abnormal T cell number / MGI
- increased T cell apoptosis / MGI
- abnormal T cell morphology / MGI
- absent T cells / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased DN3 thymocyte number / MGI
- demyelination / MGI
- abnormal immune system physiology / MGI
- abnormal T cell activation / MGI
- no phenotypic analysis / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- CNS inflammation / MGI
- abnormal immune system physiology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI