B6;C-Tg(tetO-cre)LC1Bjd/BjdCnrm
| Status | Available to order |
| EMMA ID | EM:00753 |
| International strain name | B6;C-Tg(tetO-cre)LC1Bjd/BjdCnrm |
| Alternative name | LC-1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-cre)LC1Bjd |
| Gene/Transgene symbol | Tg(tetO-cre)LC1Bjd |
Information from provider
| Provider | Hermann Bujard |
| Provider affiliation | Zentrum für Molekulare Biologie Heidelberg- ZMBH |
| Genetic information | In this strain both the luciferase (L) and the cre recombinase (C) genes with a nuclear localization signal are driven by a bidirectional, tetracycline-responsive promoter element (Ptet bi-1). |
| Phenotypic information | Mating of the (tetO-cre)LC1 strain to a strain expressing the tetracycline-controlled activator proteins tTA or rtTA, coupled to a tissue-specific promoter, results in the expression of cre recombinase and luciferase proteins in the appropriate tissue and tetracycline-inducible fashion. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Stringent doxycycline dependent control of CRE recombinase in vivo.;Schönig Kai, Schwenk Frieder, Rajewsky Klaus, Bujard Hermann, ;2002;Nucleic acids research;30;e134; 12466566
- Depot formation of doxycycline impairs Tet-regulated gene expression in vivo.;Anders Kathleen, Buschow Christian, Charo Jehad, Blankenstein Thomas, ;2012;Transgenic research;21;1099-107; 22167485
- A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells.;van de Moosdijk Anoeska Agatha Alida, van de Grift Yorick Bernardus Cornelis, de Man Saskia Madelon Ada, Zeeman Amber Lisanne, van Amerongen Renée, ;2020;Genesis (New York, N.Y. : 2000);58;e23387; 32643876
- Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes.;Denton Alice E, Carr Edward J, Magiera Lukasz P, Watts Andrew J B, Fearon Douglas T, ;2019;The Journal of experimental medicine;216;2242-2252; 31324739
- Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice.;Svensson Kristoffer, Schnyder Svenia, Cardel Bettina, Handschin Christoph, ;2016;PloS one;11;e0158716; 27463191
- Ageing compromises mouse thymus function and remodels epithelial cell differentiation.;Baran-Gale Jeanette, Morgan Michael D, Maio Stefano, Dhalla Fatima, Calvo-Asensio Irene, Deadman Mary E, Handel Adam E, Maynard Ashley, Chen Steven, Green Foad, Sit Rene V, Neff Norma F, Darmanis Spyros, Tan Weilun, May Andy P, Marioni John C, Ponting Chris P, Holländer Georg A, ;2020;eLife;9;; 32840480