C57BL/6N-Atm1Brd Dnmt3atm1a(KOMP)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:07510
International strain nameC57BL/6N-Atm1Brd Dnmt3atm1a(KOMP)Wtsi/WtsiOrl
Alternative nameEPD0332_1_C06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolDnmt3atm1a(KOMP)Wtsi
Gene/Transgene symbolDnmt3a
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0332_1_C06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased grip strength / IMPC
IMPC phenotypes (gene matching)
  • abnormal bone structure / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased grip strength / IMPC
  • decreased lean body mass / IMPC
  • decreased circulating glucose level / IMPC
  • decreased exploration in new environment / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • increased total body fat amount / IMPC
  • convulsive seizures / IMPC
  • abnormal embryo size / IMPC
MGI phenotypes (gene matching)
  • decreased body size / MGI
  • postnatal growth retardation / MGI
  • premature death / MGI
  • postnatal lethality, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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