MGI phenotypes (allele matching)
129-Elanetm1(cre)Roes/H
| Status | Available to order |
| EMMA ID | EM:00075 |
| International strain name | 129-Elanetm1(cre)Roes/H |
| Alternative name | GEcre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Elanetm1(cre)Roes, |
| Gene/Transgene symbol | Elane |
Information from provider
| Provider | Jurgen Roes |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Genetic information | Insertion of the cre recombinase at the ATG of Elane (Ela2) gene sequence. |
| Phenotypic information | Impaired innate immunity. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cyclic neutropenia / Orphanet_2686
- Autosomal dominant severe congenital neutropenia / Orphanet_486
Literature references
- Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686
- PD-L1 maintains neutrophil extracellular traps release by inhibiting neutrophil autophagy in endotoxin-induced lung injury.;Zhu Cheng-Long, Xie Jian, Zhao Zhen-Zhen, Li Peng, Liu Qiang, Guo Yu, Meng Yan, Wan Xiao-Jian, Bian Jin-Jun, Deng Xiao-Ming, Wang Jia-Feng, ;2022;Frontiers in immunology;13;949217; 36016930
- Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.;Hyun Young-Min, Sumagin Ronen, Sarangi Pranita P, Lomakina Elena, Overstreet Michael G, Baker Christina M, Fowell Deborah J, Waugh Richard E, Sarelius Ingrid H, Kim Minsoo, ;2012;The Journal of experimental medicine;209;1349-62; 22711877
- Role of β1 integrin in tissue homing of neutrophils during sepsis.;Sarangi Pranita P, Hyun Young-Min, Lerman Yelena V, Pietropaoli Anthony P, Kim Minsoo, ;2012;Shock (Augusta, Ga.);38;281-7; 22683734
- Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent.;Lerman Yelena V, Lim Kihong, Hyun Young-Min, Falkner Kathleen L, Yang Hongmei, Pietropaoli Anthony P, Sonnenberg Arnoud, Sarangi Pranita P, Kim Minsoo, ;2014;Blood;124;3515-23; 25278585
- Neutrophils support lung colonization of metastasis-initiating breast cancer cells.;Wculek Stefanie K, Malanchi Ilaria, ;2015;Nature;528;413-7; 26649828
- Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization.;Nolan Emma, Bridgeman Victoria Louise, Ombrato Luigi, Karoutas Adam, Rabas Nicolas, Sewnath Celine Angeli Natascha, Vasquez Marcos, Rodrigues Felipe Silva, Horswell Stuart, Faull Peter, Carter Rebecca, Malanchi Ilaria, ;2022;Nature cancer;3;173-187; 35221334
- GSDMD-mediated NETosis promotes the development of acute respiratory distress syndrome.;Xie Jian, Zhu Cheng-Long, Wan Xiao-Jian, Zhao Zhen-Zhen, Meng Yan, Li Peng, Guo Yu, Liu Qiang, Bian Jin-Jun, Deng Xiao-Ming, Wang Jia-Feng, ;2023;European journal of immunology;53;e2250011; 36250416
- PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy.;Zhu Cheng-Long, Xie Jian, Liu Qiang, Wang Yi, Li Hui-Ru, Yu Chang-Meng, Li Peng, Deng Xiao-Ming, Bian Jin-Jun, Wang Jia-Feng, ;2023;International journal of biological sciences;19;1413-1429; 37056920