C57BL/6N-Fgf8tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:07495
International strain nameC57BL/6N-Fgf8tm1a(KOMP)Wtsi/H
Alternative nameEPD0383_6_A10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFgf8tm1a(KOMP)Wtsi
Gene/Transgene symbolFgf8
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0383_6_A10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
MGI phenotypes (gene matching)
  • abnormal heart development / MGI
  • abnormal heart tube morphology / MGI
  • abnormal craniofacial morphology / MGI
  • syndactyly / MGI
  • abnormal pituitary gland morphology / MGI
  • abnormal hypothalamus morphology / MGI
  • absent cerebellum / MGI
  • abnormal midbrain morphology / MGI
  • open neural tube / MGI
  • small embryonic telencephalon / MGI
  • decreased body weight / MGI
  • cyanosis / MGI
  • abnormal ectoderm development / MGI
  • abnormal mesoderm development / MGI
  • absent mesoderm / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • abnormal allantois morphology / MGI
  • edema / MGI
  • prenatal lethality / MGI
  • postnatal lethality / MGI
  • abnormal developmental patterning / MGI
  • abnormal cardiovascular system morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal primitive streak morphology / MGI
  • abnormal chorion morphology / MGI
  • abnormal pharyngeal arch morphology / MGI
  • decreased neuron apoptosis / MGI
  • absent olfactory bulb / MGI
  • nervous system phenotype / MGI
  • abnormal embryonic epiblast morphology / MGI
  • abnormal craniofacial development / MGI
  • fetal growth retardation / MGI
  • abnormal neural fold formation / MGI
  • abnormal amnion morphology / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • absent somites / MGI
  • absent inferior colliculus / MGI
  • absent primitive node / MGI
  • abnormal neural crest cell apoptosis / MGI
  • abnormal truncus arteriosus septation / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • absent heart / MGI
  • abnormal cardiogenic mesoderm morphology / MGI
  • abnormal primitive streak elongation / MGI
  • third pharyngeal arch artery hypoplasia / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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