IMPC phenotypes (gene matching)
B6.129S6-Marcotm1Ktry/Oulu
| Status | Available to order |
| EMMA ID | EM:07458 |
| International strain name | B6.129S6-Marcotm1Ktry/Oulu |
| Alternative name | Marco(Tm1KTry) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Marcotm1Ktry |
| Gene/Transgene symbol | Marco |
Information from provider
| Provider | Raija Soininen |
| Provider affiliation | Biocenter Oulu, University of Oulu |
| Additional owner | The strain was generated in the laboratory of prof. Karl Tryggvason, who however has not indicated any additional conditions, just acknowledgement. |
| Genetic information | Marcotm1Ktry, same as MarcoTm1Lk. |
| Phenotypic information | Hematopoietic system, immune system. |
| Breeding history | The strain was backcrossed to C57BL/6 (Charles River) 10 generations, then homozygous mice inbred, and N10F3 mice shipped to Finland, where the strain was maintained as homozygotes for several years. Cryopreservation was done using homozygous males and C57BL/6OlaHsd females. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6OlaHsd, wild-type C57BL/6JOlaHsd |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- impaired macrophage phagocytosis / MGI
- increased inflammatory response / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- increased interferon-gamma secretion / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal dendritic cell chemotaxis / MGI
Literature references
- The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles.;Arredouani Mohamed, Yang Zhiping, Ning YaoYu, Qin Guozhong, Soininen Raija, Tryggvason Karl, Kobzik Lester, ;2004;The Journal of experimental medicine;200;267-72; 15263032
- Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A.;Chen Yunying, Pikkarainen Timo, Elomaa Outi, Soininen Raija, Kodama Tatsuhiko, Kraal Georg, Tryggvason Karl, ;2005;Journal of immunology (Baltimore, Md. : 1950);175;8173-80; 16339556