IMPC phenotypes (allele matching)
- preweaning lethality, incomplete penetrance / IMPC
B6N.Cg-Tox3tm1b(KOMP)Mbp/Orl
| Status | Available to order |
| EMMA ID | EM:07455 |
| International strain name | B6N.Cg-Tox3tm1b(KOMP)Mbp/Orl |
| Alternative name | B6;Tox3lacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tox3tm1b(KOMP)Mbp |
| Gene/Transgene symbol | Tox3 |
Information from provider
| Provider | Richard Iggo |
| Provider affiliation | Unite INSERM, Institut Bergonie |
| Genetic information | lacZ knock-in replaces exons 5-6 of Tox3, deleting the Tox3 HMG box DNA binding domain. TOX3 is a GWAS breast cancer predisposition gene. Derived from Tox3tm1a(KOMP)Mbp by crossing with Stella-Cre mice. |
| Phenotypic information | Homozygous:Homozygotes die at birth, possibly from neurological problems. Strong neural tube staining in Xgal. Weak mammary bud staining in Xgal.Heterozygous:Heterozygotes are healthy and fertile with no obvious mammary phenotype. |
| Breeding history | Tox3tm1a(KOMP)Mbp mice from UC Davis were crossed with Stella-Cre mice from Sanger, to delete neo cassette and Tox3 exons 5-6. Currently about 5 generations of backcrossing to C57BL/6N. KOMP tm1a mice were pure C57BL/6N. Stella-Cre mice were on a mixed background. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- Genome-wide association study identifies novel breast cancer susceptibility loci.;Easton Douglas F, Pooley Karen A, Dunning Alison M, Pharoah Paul D P, Thompson Deborah, Ballinger Dennis G, Struewing Jeffery P, Morrison Jonathan, Field Helen, Luben Robert, Wareham Nicholas, Ahmed Shahana, Healey Catherine S, Bowman Richard, null null, Meyer Kerstin B, Haiman Christopher A, Kolonel Laurence K, Henderson Brian E, Le Marchand Loic, Brennan Paul, Sangrajrang Suleeporn, Gaborieau Valerie, Odefrey Fabrice, Shen Chen-Yang, Wu Pei-Ei, Wang Hui-Chun, Eccles Diana, Evans D Gareth, Peto Julian, Fletcher Olivia, Johnson Nichola, Seal Sheila, Stratton Michael R, Rahman Nazneen, Chenevix-Trench Georgia, Bojesen Stig E, Nordestgaard Børge G, Axelsson Christen K, Garcia-Closas Montserrat, Brinton Louise, Chanock Stephen, Lissowska Jolanta, Peplonska Beata, Nevanlinna Heli, Fagerholm Rainer, Eerola Hannaleena, Kang Daehee, Yoo Keun-Young, Noh Dong-Young, Ahn Sei-Hyun, Hunter David J, Hankinson Susan E, Cox David G, Hall Per, Wedren Sara, Liu Jianjun, Low Yen-Ling, Bogdanova Natalia, Schürmann Peter, Dörk Thilo, Tollenaar Rob A E M, Jacobi Catharina E, Devilee Peter, Klijn Jan G M, Sigurdson Alice J, Doody Michele M, Alexander Bruce H, Zhang Jinghui, Cox Angela, Brock Ian W, MacPherson Gordon, Reed Malcolm W R, Couch Fergus J, Goode Ellen L, Olson Janet E, Meijers-Heijboer Hanne, van den Ouweland Ans, Uitterlinden André, Rivadeneira Fernando, Milne Roger L, Ribas Gloria, Gonzalez-Neira Anna, Benitez Javier, Hopper John L, McCredie Margaret, Southey Melissa, Giles Graham G, Schroen Chris, Justenhoven Christina, Brauch Hiltrud, Hamann Ute, Ko Yon-Dschun, Spurdle Amanda B, Beesley Jonathan, Chen Xiaoqing, null null, null null, Mannermaa Arto, Kosma Veli-Matti, Kataja Vesa, Hartikainen Jaana, Day Nicholas E, Cox David R, Ponder Bruce A J, ;2007;Nature;447;1087-93; 17529967