C57BL/6N-Ntrk2tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:07446
Citation informationRRID:IMSR_EM:07446 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Ntrk2tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0591_5_A03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNtrk2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolNtrk2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0591_5_A03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased lean body mass / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal rib morphology / IMPC
  • decreased prepulse inhibition / IMPC
  • increased circulating HDL cholesterol level / IMPC
MGI phenotypes (gene matching)
  • abnormal inner ear vestibule morphology / MGI
  • abnormal liver morphology / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal amygdala morphology / MGI
  • abnormal cerebellum development / MGI
  • small facial motor nucleus / MGI
  • decreased motor neuron number / MGI
  • abnormal somatic sensory system morphology / MGI
  • small dorsal root ganglion / MGI
  • decreased sensory neuron number / MGI
  • abnormal sensory neuron innervation pattern / MGI
  • absent hair-down neurons / MGI
  • small L4 dorsal root ganglion / MGI
  • abnormal vestibulocochlear nerve morphology / MGI
  • small geniculate ganglion / MGI
  • small petrosal ganglion / MGI
  • small nodose ganglion / MGI
  • small trigeminal ganglion / MGI
  • impaired ovarian folliculogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal optic nerve morphology / MGI
  • abnormal eyelid morphology / MGI
  • hyperactivity / MGI
  • absent suckling reflex / MGI
  • no swallowing reflex / MGI
  • reduced long term potentiation / MGI
  • abnormal vibrissae reflex / MGI
  • impaired righting response / MGI
  • postnatal growth retardation / MGI
  • increased circulating adrenocorticotropin level / MGI
  • impaired synaptic plasticity / MGI
  • abnormal breathing pattern / MGI
  • increased circulating insulin level / MGI
  • abnormal vision / MGI
  • no abnormal phenotype detected / MGI
  • gliosis / MGI
  • abnormal innervation / MGI
  • abnormal long term potentiation / MGI
  • neurodegeneration / MGI
  • abnormal pupillary reflex / MGI
  • decreased circulating adrenocorticotropin level / MGI
  • decreased circulating corticosterone level / MGI
  • abnormal somatic nervous system morphology / MGI
  • decreased circulating follicle stimulating hormone level / MGI
  • increased thigmotaxis / MGI
  • abnormal cochlear ganglion morphology / MGI
  • abnormal vestibular ganglion morphology / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • increased susceptibility to age related obesity / MGI
  • abnormal dopaminergic neuron morphology / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • astrocytosis / MGI
  • impaired granulosa cell differentiation / MGI
  • abnormal response to novel object / MGI
  • nervous system phenotype / MGI
  • abnormal axon extension / MGI
  • small cochlear ganglion / MGI
  • small vestibular ganglion / MGI
  • abnormal barrel cortex morphology / MGI
  • abnormal rod electrophysiology / MGI
  • abnormal peripheral nervous system regeneration / MGI
  • abnormal utricular macula morphology / MGI
  • abnormal crista ampullaris neuroepithelium morphology / MGI
  • abnormal vestibular labyrinth morphology / MGI
  • abnormal type I vestibular cell / MGI
  • abnormal vestibular nerve morphology / MGI
  • abnormal distortion product otoacoustic emission / MGI
  • abnormal cochlear OHC afferent innervation pattern / MGI
  • abnormal circulating corticosterone level / MGI
  • growth/size/body region phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • behavior/neurological phenotype / MGI
  • increased circulating leptin level / MGI
  • abnormal neuronal migration / MGI
  • decreased retinal ganglion cell number / MGI
  • abnormal retinal ganglion cell morphology / MGI
  • decreased amacrine cell number / MGI
  • abnormal dendrite morphology / MGI
  • abnormal adrenal gland zona fasciculata morphology / MGI
  • adrenal cortical hyperplasia / MGI
  • abnormal spatial working memory / MGI
  • abnormal retinal rod cell outer segment morphology / MGI
  • abnormal Purkinje cell dendrite morphology / MGI
  • increased abdominal fat pad weight / MGI
  • abnormal secondary ovarian follicle morphology / MGI
  • abnormal axon fasciculation / MGI
  • abnormal synapse morphology / MGI
  • abnormal retinal development / MGI
  • abnormal neuron differentiation / MGI
  • mortality/aging / MGI
  • abnormal survival / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • decreased dopaminergic neuron number / MGI
  • increased susceptibility to dopaminergic neuron neurotoxicity / MGI

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