C57BL/6N-Atm1Brd Grm8tm2a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:07403
International strain nameC57BL/6N-Atm1Brd Grm8tm2a(KOMP)Wtsi/WtsiH
Alternative nameEPD0655_1_E11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGrm8tm2a(KOMP)Wtsi
Gene/Transgene symbolGrm8
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0655_1_E11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Functional analysis of candidate genes from genome-wide association studies of hearing.;Ingham Neil J, Rook Victoria, Di Domenico Francesca, James Elysia, Lewis Morag A, Girotto Giorgia, Buniello Annalisa, Steel Karen P, ;2020;Hearing research;387;107879; 31927188

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal retina morphology / IMPC
IMPC phenotypes (gene matching)
  • abnormal retina morphology / IMPC
MGI phenotypes (gene matching)
  • increased body weight / MGI
  • increased anxiety-related response / MGI
  • abnormal locomotor behavior / MGI
  • decreased exploration in new environment / MGI
  • impaired swimming / MGI
  • insulin resistance / MGI
  • increased percent body fat/body weight / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased prepulse inhibition / MGI

Literature references

  • Functional analysis of candidate genes from genome-wide association studies of hearing.;Ingham Neil J, Rook Victoria, Di Domenico Francesca, James Elysia, Lewis Morag A, Girotto Giorgia, Buniello Annalisa, Steel Karen P, ;2020;Hearing research;387;107879; 31927188
  • Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity.;Nabit Bretton P, Taylor Anne, Winder Danny G, ;2024;The Journal of neuroscience : the official journal of the Society for Neuroscience;44;; 38918065

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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