MGI phenotypes (allele matching)
129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H
| Status | Available to order |
| EMMA ID | EM:00074 |
| Citation information | RRID:IMSR_EM:00074 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H |
| Alternative name | GECG |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ctsgtm1.1Roes, Elanetm1(cre)Roes |
| Gene/Transgene symbol | Ctsg, Elane |
Information from provider
| Provider | Jurgen Roes |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Genetic information | Double mutant generated by intercrossing Elane (Ela2)- and Ctsg-deficient mice. |
| Phenotypic information | Impaired innate immunity. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cyclic neutropenia / Orphanet_2686
- Autosomal dominant severe congenital neutropenia / Orphanet_486
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- enlarged liver / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- neoplasm / MGI
- increased leukemia incidence / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal bone marrow cell morphology/development / MGI
- thrombocytopenia / MGI
- increased acute promyelocytic leukemia incidence / MGI
- increased spleen weight / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal inflammatory response / MGI
- no abnormal phenotype detected / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal neutrophil physiology / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased tumor necrosis factor secretion / MGI
- impaired neutrophil recruitment / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
Literature references
- Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686
- Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice.;Hahn Ines, Klaus Anna, Janze Ann-Kathrin, Steinwede Kathrin, Ding Nadine, Bohling Jennifer, Brumshagen Christina, Serrano Hélène, Gauthier Francis, Paton James C, Welte Tobias, Maus Ulrich A, ;2011;Infection and immunity;79;4893-901; 21911460