MGI phenotypes (allele matching)
129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H
| Status | Available to order |
| EMMA ID | EM:00074 |
| International strain name | 129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H |
| Alternative name | GECG |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ctsgtm1.1Roes, Elanetm1(cre)Roes |
| Gene/Transgene symbol | Ctsg, Elane |
Information from provider
| Provider | Jurgen Roes |
| Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
| Genetic information | Double mutant generated by intercrossing Elane (Ela2)- and Ctsg-deficient mice. |
| Phenotypic information | Impaired innate immunity. |
| References |
|
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cyclic neutropenia / Orphanet_2686
- Autosomal dominant severe congenital neutropenia / Orphanet_486
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- enlarged liver / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- anemia / MGI
- abnormal myelopoiesis / MGI
- neoplasm / MGI
- increased leukemia incidence / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal bone marrow cell morphology/development / MGI
- thrombocytopenia / MGI
- increased acute promyelocytic leukemia incidence / MGI
- increased spleen weight / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal inflammatory response / MGI
- no abnormal phenotype detected / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal neutrophil physiology / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased tumor necrosis factor secretion / MGI
- impaired neutrophil recruitment / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
Literature references
- Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686
- Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice.;Hahn Ines, Klaus Anna, Janze Ann-Kathrin, Steinwede Kathrin, Ding Nadine, Bohling Jennifer, Brumshagen Christina, Serrano Hélène, Gauthier Francis, Paton James C, Welte Tobias, Maus Ulrich A, ;2011;Infection and immunity;79;4893-901; 21911460