129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H
Status | Available to order |
EMMA ID | EM:00074 |
International strain name | 129-Elanetm1(cre)Roes Ctsgtm1.1Roes/H |
Alternative name | GECG |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Elanetm1(cre)Roes, |
Gene/Transgene symbol | Elane |
Information from provider
Provider | Jurgen Roes |
Provider affiliation | Windeyer Institute of Medical Sciences, University College London |
Genetic information | Double mutant generated by intercrossing Elane (Ela2)- and Ctsg-deficient mice. |
Phenotypic information | Impaired innate immunity. |
References |
|
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cyclic neutropenia / Orphanet_2686
- Autosomal dominant severe congenital neutropenia / Orphanet_486
MGI phenotypes (allele matching)
Literature references
- Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.;Tkalcevic J, Novelli M, Phylactides M, Iredale J P, Segal A W, Roes J, ;2000;Immunity;12;201-10; 10714686
- Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice.;Hahn Ines, Klaus Anna, Janze Ann-Kathrin, Steinwede Kathrin, Ding Nadine, Bohling Jennifer, Brumshagen Christina, Serrano Hélène, Gauthier Francis, Paton James C, Welte Tobias, Maus Ulrich A, ;2011;Infection and immunity;79;4893-901; 21911460
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).