C57BL/6N-Atm1Brd Adamts3tm1a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:07375
International strain nameC57BL/6N-Atm1Brd Adamts3tm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0660_2_C10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAdamts3tm1a(KOMP)Wtsi
Gene/Transgene symbolAdamts3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0660_2_C10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • double outlet right ventricle / MGI
  • small liver / MGI
  • abnormal forebrain morphology / MGI
  • abnormal lateral ventricle morphology / MGI
  • abnormal third ventricle morphology / MGI
  • abnormal fourth ventricle morphology / MGI
  • abnormal hindbrain morphology / MGI
  • abnormal placenta labyrinth morphology / MGI
  • skin edema / MGI
  • abnormal erythrocyte morphology / MGI
  • liver degeneration / MGI
  • aorta coarctation / MGI
  • bifid ureter / MGI
  • dilated ureter / MGI
  • pallor / MGI
  • abnormal Mullerian duct morphology / MGI
  • abnormal Wolffian duct morphology / MGI
  • increased hepatocyte apoptosis / MGI
  • abnormal adenohypophysis morphology / MGI
  • basisphenoid bone foramen / MGI
  • fusion of vertebral arches / MGI
  • absent stapedial artery / MGI
  • hemopericardium / MGI
  • skeleton phenotype / MGI
  • abnormal lymphangiogenesis / MGI
  • abnormal cervical rib / MGI
  • thoracoschisis / MGI
  • abnormal liver parenchyma morphology / MGI
  • abnormal optic chiasm morphology / MGI
  • absent lymphatic vessels / MGI
  • perimembraneous ventricular septal defect / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • abnormal vertebral artery morphology / MGI
  • abnormal placenta fetal blood space morphology / MGI
  • dual inferior vena cava / MGI
  • abnormal basilar artery morphology / MGI
  • absent segment of anterior cerebral artery / MGI
  • retropleural edema / MGI
  • subcutaneous edema / MGI
  • abnormal Mullerian duct topology / MGI
  • abnormal vitelline vein connection / MGI
  • trigeminal neuroma / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal ductus venosus valve topology / MGI
  • multiple persisting craniopharyngeal ducts / MGI
  • abnormal vitelline vein topology / MGI
  • persistent dorsal ophthalmic artery / MGI
  • embryo cyst / MGI
  • heterochrony / MGI
  • hemangioma / MGI
  • abnormal brain artery topology / MGI
  • persistent trigeminal artery / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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