IMPC phenotypes (gene matching)
C57BL/6NTac-Alms1tm1e(EUCOMM)Hmgu/H
| Status | Available to order |
| EMMA ID | EM:07351 |
| International strain name | C57BL/6NTac-Alms1tm1e(EUCOMM)Hmgu/H |
| Alternative name | HEPD0522_6_E07 |
| Strain type | Targeted Mutant Strains : Targeted Non-conditional |
| Allele/Transgene symbol | Alms1tm1e(EUCOMM)Hmgu |
| Gene/Transgene symbol | Alms1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0522_6_E07. For further details on the construction of this clone see the page at the IMPC portal. The targeted allele has lost the 3' loxP site. These mutations cannot be converted into conditional alleles. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Alström syndrome / Orphanet_64
MGI phenotypes (gene matching)
- increased white adipose tissue amount / MGI
- abnormal circulating cholesterol level / MGI
- enlarged liver / MGI
- abnormal hepatocyte morphology / MGI
- small gonad / MGI
- seminiferous tubule degeneration / MGI
- abnormal spermatogenesis / MGI
- increased body weight / MGI
- obese / MGI
- increased body size / MGI
- retinal degeneration / MGI
- increased circulating triglyceride level / MGI
- increased circulating HDL cholesterol level / MGI
- hyperglycemia / MGI
- increased circulating insulin level / MGI
- abnormal seminiferous tubule morphology / MGI
- hepatic steatosis / MGI
- dilated renal tubules / MGI
- albuminuria / MGI
- increased urine protein level / MGI
- increased liver weight / MGI
- enlarged kidney / MGI
- liver fibrosis / MGI
- abnormal retinal outer nuclear layer morphology / MGI
- increased kidney weight / MGI
- abnormal proximal convoluted tubule morphology / MGI
- increased circulating cholesterol level / MGI
- abnormal eye physiology / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- cellular phenotype / MGI
- increased susceptibility to weight gain / MGI
- pancreatic islet hyperplasia / MGI
- retinal pigment epithelium atrophy / MGI
- abnormal eye electrophysiology / MGI
- increased circulating leptin level / MGI
- increased fat cell size / MGI
- impaired hearing / MGI
- retinal photoreceptor degeneration / MGI
- retinal outer nuclear layer degeneration / MGI
- dilated proximal convoluted tubules / MGI
- degranulated pancreatic beta cells / MGI
- crystalluria / MGI
- increased total body fat amount / MGI
- abnormal renal tubule epithelial cell primary cilium morphology / MGI
- increased kidney apoptosis / MGI
- tubulointerstitial nephritis / MGI
- increased kidney cell proliferation / MGI
- increased food intake / MGI
- increased or absent threshold for auditory brainstem response / MGI
- increased fasted circulating glucose level / MGI