C57BL/6N-Ntrk1^{tm1a(EUCOMM)Wtsi}/H

Status	Available to order
EMMA ID	EM:07342
International strain name	C57BL/6N-Ntrk1^{tm1a(EUCOMM)Wtsi}/H
Alternative name	EPD0688_6_D04
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Ntrk1^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Ntrk1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from EUCOMM ES clone EPD0688_6_D04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Hereditary sensory and autonomic neuropathy type 4 / Orphanet_642
Familial medullary thyroid carcinoma / Orphanet_99361

IMPC phenotypes (gene matching)

increased basophil cell number / IMPC
preweaning lethality, complete penetrance / IMPC

MGI phenotypes (gene matching)

mottled coat / MGI
ulcerated paws / MGI
small dorsal root ganglion / MGI
decreased sensory neuron number / MGI
abnormal sensory neuron innervation pattern / MGI
abnormal sympathetic ganglion morphology / MGI
small superior cervical ganglion / MGI
abnormal cholinergic neuron morphology / MGI
small trigeminal ganglion / MGI
skin lesions / MGI
decreased body size / MGI
corneal opacity / MGI
blepharoptosis / MGI
abnormal vibrissae reflex / MGI
unresponsive to tactile stimuli / MGI
abnormal pain threshold / MGI
increased thermal nociceptive threshold / MGI
miotic pupils / MGI
premature death / MGI
abnormal digit morphology / MGI
no abnormal phenotype detected / MGI
abnormal chemical nociception / MGI
abnormal nociception after inflammation / MGI
no phenotypic analysis / MGI
nervous system phenotype / MGI
abnormal thermosensation / MGI
decreased thermal nociceptive threshold / MGI
abnormal sympathetic nervous system physiology / MGI
abnormal proprioceptive neuron morphology / MGI
abnormal neuron physiology / MGI
hearing/vestibular/ear phenotype / MGI
behavior/neurological phenotype / MGI
abnormal neurite morphology / MGI
increased muscle spindle number / MGI
abnormal sensory neuron physiology / MGI
mortality/aging / MGI
postnatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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