MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
C57BL/6N-Tg(Tnfrsf19-cre/ERT2)1Kori/Ph
| Status | Available to order |
| EMMA ID | EM:07327 |
| International strain name | C57BL/6N-Tg(Tnfrsf19-cre/ERT2)1Kori/Ph |
| Alternative name | TROY-CreERT2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tnfrsf19-cre/ERT2)1Kori |
| Gene/Transgene symbol | Tg(Tnfrsf19-cre/ERT2)1Kori |
Information from provider
| Provider | Vladimir Korinek |
| Provider affiliation | Cell and Developmental Biology, Institute of Molecular Genetics of the ASCR, v. v. i. |
| Genetic information | C57BL/6N mouse oocytes were injected by RP23-166C22 BAC DNA containing whole Tnfrsf19 (Troy) gene with 65, 88 kbp overhangs on 5', 3' ends, respectively. CreERT2 coding sequence is incorporated into translation initiating ATG of second exon of Tnfrsf19 gene. These mice should provide an insight to importance of Tnfrsf19 gene in context of Wnt signaling. This will be achievable after crossbreeding with either loxP reporter mice or another loxP mouse which will ablates Wnt signaling in cells where Cre recombinase is expressed. |
| Phenotypic information | The mouse strain does not show specific phenotype. |
| Breeding history | Mouse strain is kept on heterozygous basis. Transgenic animals are crossed with C57BL/6N partners. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Literature references
- Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.;Fafilek Bohumil, Krausova Michaela, Vojtechova Martina, Pospichalova Vendula, Tumova Lucie, Sloncova Eva, Huranova Martina, Stancikova Jitka, Hlavata Adela, Svec Jiri, Sedlacek Radislav, Luksan Ondrej, Oliverius Martin, Voska Ludek, Jirsa Milan, Paces Jan, Kolar Michal, Krivjanska Maria, Klimesova Klara, Tlaskalova-Hogenova Helena, Korinek Vladimir, ;2013;Gastroenterology;144;381-391; 23142137