B6;FVB-Tg(Pcp2-cre)756Mro/H

Status

Available to order

EMMA IDEM:07326
International strain nameB6;FVB-Tg(Pcp2-cre)756Mro/H
Alternative nameL7 Cre
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Pcp2-cre)756Mro
Gene/Transgene symbolTg(Pcp2-cre)756Mro

Information from provider

ProviderSebastian Brandner
Provider affiliationDivision of Neuropathology, Institute of Neurology, University College London
Genetic informationThe transgene carried a cre cDNA fragment cloned into exon 4 of the Pcp2 gene and promoter. Transgenic mice show restricted expression of Cre recombinase in Purkinje cells.
Phenotypic informationTransgenic mice show restricted expression of Cre recombinase in Purkinje cells.
Breeding historyOutbred onto C57BL/6.
References
  • PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320
  • Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella.;Nayeem Naushaba, Kerr Fiona, Naumann Heike, Linehan Jackie, Lovestone Simon, Brandner Sebastian, ;2007;Molecular and cellular neurosciences;34;400-8; 17208451
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320
  • Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella.;Nayeem Naushaba, Kerr Fiona, Naumann Heike, Linehan Jackie, Lovestone Simon, Brandner Sebastian, ;2007;Molecular and cellular neurosciences;34;400-8; 17208451

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).