B6;FVB-Tg(Pcp2-cre)756Mro/H
| Status | Available to order |
| EMMA ID | EM:07326 |
| Citation information | RRID:IMSR_EM:07326 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;FVB-Tg(Pcp2-cre)756Mro/H |
| Alternative name | L7 Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Pcp2-cre)756Mro |
| Gene/Transgene symbol | Tg(Pcp2-cre)756Mro |
Information from provider
| Provider | Sebastian Brandner |
| Provider affiliation | Division of Neuropathology, Institute of Neurology, University College London |
| Genetic information | The transgene carried a cre cDNA fragment cloned into exon 4 of the Pcp2 gene and promoter. Transgenic mice show restricted expression of Cre recombinase in Purkinje cells. |
| Phenotypic information | Transgenic mice show restricted expression of Cre recombinase in Purkinje cells. |
| Breeding history | Outbred onto C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320
- Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella.;Nayeem Naushaba, Kerr Fiona, Naumann Heike, Linehan Jackie, Lovestone Simon, Brandner Sebastian, ;2007;Molecular and cellular neurosciences;34;400-8; 17208451