IMPC phenotypes (gene matching)
C57BL/6N-Pink1tm1a(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:07320 |
| International strain name | C57BL/6N-Pink1tm1a(EUCOMM)Wtsi/H |
| Alternative name | EPD0787_2_G02 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Pink1tm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Pink1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0787_2_G02. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Young-onset Parkinson disease / Orphanet_2828
MGI phenotypes (gene matching)
- abnormal cerebral cortex morphology / MGI
- decreased body weight / MGI
- abnormal social investigation / MGI
- hypoactivity / MGI
- abnormal gait / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- extended life span / MGI
- abnormal olfaction / MGI
- abnormal sensory capabilities/reflexes/nociception / MGI
- abnormal innervation / MGI
- abnormal nervous system electrophysiology / MGI
- no phenotypic analysis / MGI
- increased neuron apoptosis / MGI
- abnormal dopaminergic neuron morphology / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- oxidative stress / MGI
- abnormal neuron physiology / MGI
- abnormal lysosome morphology / MGI
- endocrine/exocrine gland phenotype / MGI
- cellular phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal cell physiology / MGI
- decreased dopamine level / MGI
- abnormal mitochondrion morphology / MGI
- abnormal mitochondrial physiology / MGI
- increased interleukin-1 beta secretion / MGI
- increased interleukin-10 secretion / MGI
- increased interleukin-12 secretion / MGI
- increased sensitivity to induced cell death / MGI
- abnormal olfactory bulb glomerular layer morphology / MGI
- abnormal cellular respiration / MGI
- abnormal respiratory electron transport chain / MGI
- abnormal mitochondrial ATP synthesis coupled electron transport / MGI