MGI phenotypes (allele matching)
STOCK G6pdxa-m1Neu/H
| Status | Available to order |
| EMMA ID | EM:00073 |
| International strain name | STOCK G6pdxa-m1Neu/H |
| Alternative name | glucose-6-phosphate |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | G6pdxa-m1Neu |
| Gene/Transgene symbol | G6pdx |
Information from provider
| Provider | Walter Pretsch |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Phenotypic information | Low glucose-6-phosphate dehydrogenase, a activity variant. Described in 'Genetic variants and strains of the laboratory mouse' (page 273) and by Charles & Pretsch (1984; Mouse News Letters, 71; 37-38) as having three levels of G6PD activity: 20% in hemizygous males, 60% in heterozygous females and 15% in homozygous females compared to wild-type. Similar levels (12%, 56% and 9% of wild-type respectively) were seen by Peters et al. (Genet Res 52:195-201). Peters et al. reported a reduced recombination frequency between Hq-G6pd-Ta suggesting the X chromosome carrying G6pdx suppresses recombination in this region, but no evidence of a structural rearrangement was detected cytologically. Peters & Ball (Genet Res 56: 245-252) showed greater expression of G6PD in the blood of G6pdx/G6pdx than in the reciprocal (maternal allele quoted first). This difference was greater in older mice (2-6 months) than in younger mice (one month). Sanders et al. (Mut Res 374:79-87) reported finding an A to T transversion in the G6pdx gene, at the 5' splice site consensus sequence at the 3' end of exon 1, part of the untranslated region, which is a likely cause of the lowered activity. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (gene matching)
- abnormal heart morphology / MGI
- altered response to myocardial infarction / MGI
- abnormal blood vessel morphology / MGI
- abnormal placenta labyrinth morphology / MGI
- hemorrhage / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal chorion morphology / MGI
- paternal imprinting / MGI
- nervous system phenotype / MGI
- increased allantois apoptosis / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- small placenta / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- hematopoietic system phenotype / MGI
- abnormal paraxial mesoderm morphology / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- embryo tissue necrosis / MGI
- increased embryonic tissue cell apoptosis / MGI
Literature references
- X-linked glucose-6-phosphate dehydrogenase deficiency in Mus musculus.;Pretsch W, Charles D J, Merkle S, ;1988;Biochemical genetics;26;89-103; 3377761
- Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension.;Varghese Mathews Valuparampil, James Joel, Rafikova Olga, Rafikov Ruslan, ;2021;American journal of physiology. Lung cellular and molecular physiology;320;L508-L521; 33502933
- G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea.;White Karessa, Kim Mi-Jung, Ding Dalian, Han Chul, Park Hyo-Jin, Meneses Zaimary, Tanokura Masaru, Linser Paul, Salvi Richard, Someya Shinichi, ;2017;The Journal of neuroscience : the official journal of the Society for Neuroscience;37;5770-5781; 28473643