MGI phenotypes (allele matching)
STOCK G6pdxa-m1Neu/H
| Status | Available to order |
| EMMA ID | EM:00073 |
| Citation information | RRID:IMSR_EM:00073 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK G6pdxa-m1Neu/H |
| Alternative name | glucose-6-phosphate |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | G6pdxa-m1Neu |
| Gene/Transgene symbol | G6pdx |
Information from provider
| Provider | Walter Pretsch |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Phenotypic information | Low glucose-6-phosphate dehydrogenase, a activity variant. Described in 'Genetic variants and strains of the laboratory mouse' (page 273) and by Charles & Pretsch (1984; Mouse News Letters, 71; 37-38) as having three levels of G6PD activity: 20% in hemizygous males, 60% in heterozygous females and 15% in homozygous females compared to wild-type. Similar levels (12%, 56% and 9% of wild-type respectively) were seen by Peters et al. (Genet Res 52:195-201). Peters et al. reported a reduced recombination frequency between Hq-G6pd-Ta suggesting the X chromosome carrying G6pdx suppresses recombination in this region, but no evidence of a structural rearrangement was detected cytologically. Peters & Ball (Genet Res 56: 245-252) showed greater expression of G6PD in the blood of G6pdx/G6pdx than in the reciprocal (maternal allele quoted first). This difference was greater in older mice (2-6 months) than in younger mice (one month). Sanders et al. (Mut Res 374:79-87) reported finding an A to T transversion in the G6pdx gene, at the 5' splice site consensus sequence at the 3' end of exon 1, part of the untranslated region, which is a likely cause of the lowered activity. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (gene matching)
- abnormal heart morphology / MGI
- altered response to myocardial infarction / MGI
- abnormal blood vessel morphology / MGI
- abnormal placenta labyrinth morphology / MGI
- hemorrhage / MGI
- abnormal extraembryonic tissue morphology / MGI
- abnormal chorion morphology / MGI
- paternal imprinting / MGI
- nervous system phenotype / MGI
- increased allantois apoptosis / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- small placenta / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- hematopoietic system phenotype / MGI
- abnormal paraxial mesoderm morphology / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- embryo tissue necrosis / MGI
- increased embryonic tissue cell apoptosis / MGI
Literature references
- X-linked glucose-6-phosphate dehydrogenase deficiency in Mus musculus.;Pretsch W, Charles D J, Merkle S, ;1988;Biochemical genetics;26;89-103; 3377761
- Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension.;Varghese Mathews Valuparampil, James Joel, Rafikova Olga, Rafikov Ruslan, ;2021;American journal of physiology. Lung cellular and molecular physiology;320;L508-L521; 33502933
- G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea.;White Karessa, Kim Mi-Jung, Ding Dalian, Han Chul, Park Hyo-Jin, Meneses Zaimary, Tanokura Masaru, Linser Paul, Salvi Richard, Someya Shinichi, ;2017;The Journal of neuroscience : the official journal of the Society for Neuroscience;37;5770-5781; 28473643