C57BL/6N-Ahnaktm1a(KOMP)Mbp/H

Status

Available to order

EMMA IDEM:07247
Citation informationRRID:IMSR_EM:07247 

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International strain nameC57BL/6N-Ahnaktm1a(KOMP)Mbp/H
Alternative nameDEPD00526_6_A01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAhnaktm1a(KOMP)Mbp
Gene/Transgene symbolAhnak
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone DEPD00526_6_A01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • improved glucose tolerance / IMPC
  • increased large unstained cell number / IMPC
  • increased monocyte cell number / IMPC
MGI phenotypes (gene matching)
  • decreased body weight / MGI
  • abnormal T cell activation / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to parasitic infection / MGI
  • decreased T cell proliferation / MGI
  • abnormal T-helper 1 physiology / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • increased interleukin-4 secretion / MGI
  • decreased total body fat amount / MGI

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Practical information

Genotyping protocol

Example health report
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