IMPC phenotypes (gene matching)
B6.129P2-Faddtm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07233 |
| International strain name | B6.129P2-Faddtm1Mak/Cnbc |
| Alternative name | FADD/FLIP (Fadd |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Faddtm1Mak |
| Gene/Transgene symbol | Fadd |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | The targeting construct replaces the entire coding region (2 exons) with PGK Neo gene in the reverse orientation. |
| Phenotypic information | Mice with a deletion in the FADD gene did not survive beyond day 11.5 of embryogenesis; these mice showed signs of cardiac failure and abdominal hemorrhage. |
| Breeding history | Pure C57BL/6, backcrossed 10 times. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- FADD-related immunodeficiency / Orphanet_306550
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- trabecula carnea hypoplasia / MGI
- internal hemorrhage / MGI
- decreased embryo size / MGI
- thin myocardium / MGI
- embryonic growth retardation / MGI
- abnormal myocardium layer morphology / MGI
- embryonic lethality / MGI
- decreased sensitivity to induced cell death / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- decreased fibroblast apoptosis / MGI
Literature references
- Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.;Yeh W C, Itie A, Elia A J, Ng M, Shu H B, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel D V, Mak T W, ;2000;Immunity;12;633-42; 10894163
- FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.;Yeh W C, de la Pompa J L, McCurrach M E, Shu H B, Elia A J, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry W S, Lowe S W, Goeddel D V, Mak T W, ;1998;Science (New York, N.Y.);279;1954-8; 9506948