IMPC phenotypes (gene matching)
- decreased body weight / IMPC
B6.129P2-Anp32etm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07231 |
| International strain name | B6.129P2-Anp32etm1Mak/Cnbc |
| Alternative name | ANP32E (Anp32e |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Anp32etm1Mak |
| Gene/Transgene symbol | Anp32e |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | Targeting construct replaced exons 2 to 6 with a pgk-neo cassette. |
| Phenotypic information | We demonstrate that the Anp32e gene can be deleted in mice without any apparent effect on their wellbeing. No defects in thymocyte apoptosis in response to various stresses, fibroblast growth, gross behaviour, physical ability, or pathogenesis were detected. Furthermore, combined deletion of Anp32a and Anp32e also resulted in a viable and apparently healthy mouse. |
| Breeding history | Pure C57BL/6, backcrossed 10 times. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Literature references
- Generation and characterization of the Anp32e-deficient mouse.;Reilly Patrick T, Afzal Samia, Wakeham Andrew, Haight Jillian, You-Ten Annick, Zaugg Kathrin, Dembowy Joanna, Young Ashley, Mak Tak W, ;2010;PloS one;5;e13597; 21049064
- CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.;Gopinathan Gokul, Xu Qian, Luan Xianghong, Diekwisch Thomas G H, ;2024;PLoS biology;22;e3002574; 38630655