IMPC phenotypes (gene matching)
B6.129P2-Trim3tm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07229 |
| International strain name | B6.129P2-Trim3tm1Mak/Cnbc |
| Alternative name | Berp (Trim3 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trim3tm1Mak |
| Gene/Transgene symbol | Trim3 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | The targeting construct replaced Exons 1 and 2 with a neomycin cassette in the reverse direction of transcription. |
| Phenotypic information | BERP-deficient mice exhibit increased resistance to pentylenetetrazol-induced seizures. |
| Breeding history | Pure C57BL/6, backcrossed 10 times. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
Literature references
- Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.;Cheung Carol C, Yang Caimei, Berger Thorsten, Zaugg Kathrin, Reilly Patrick, Elia Andrew J, Wakeham Andrew, You-Ten Annick, Chang Ning, Li Lijun, Wan Qi, Mak Tak Wah, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;11883-8; 20543135