| Status | Available to order |
| EMMA ID | EM:07228 |
| Citation information | RRID:IMSR_EM:07228 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.129-Cd8atm1Mak/Cnbc |
| Alternative name | CD8 Lyt-2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd8atm1Mak |
| Gene/Transgene symbol | Cd8a |
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the (Cd8a) Lyt-2 gene using embryonic stem cell technology. |
| Phenotypic information | In these mice, CD8+ T lymphocytes are not present in peripheral lymphoid organs, but the CD4+ T lymphocyte population seems to be unaltered. Cytotoxic response of T lymphocytes from these mice against alloantigens and viral antigens is dramatically decreased. Proliferative response against alloantigens and in vivo help to B lymphocytes, however, are not affected. |
| Breeding history | Pure BALB/c, backcrossed 10 times. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous BALB/c males, wild-type BALB/c females |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
