| Status | Available to order |
| EMMA ID | EM:07228 |
| International strain name | C.129-Cd8atm1Mak/Cnbc |
| Alternative name | CD8 Lyt-2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd8atm1Mak |
| Gene/Transgene symbol | Cd8a |
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the (Cd8a) Lyt-2 gene using embryonic stem cell technology. |
| Phenotypic information | In these mice, CD8+ T lymphocytes are not present in peripheral lymphoid organs, but the CD4+ T lymphocyte population seems to be unaltered. Cytotoxic response of T lymphocytes from these mice against alloantigens and viral antigens is dramatically decreased. Proliferative response against alloantigens and in vivo help to B lymphocytes, however, are not affected. |
| Breeding history | Pure BALB/c, backcrossed 10 times. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous BALB/c, wild-type BALB/c |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
