B6.129P2-Cd34tm1Szk/Cnbc

Status

Available to order

EMMA IDEM:07223
Citation informationRRID:IMSR_EM:07223 

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International strain nameB6.129P2-Cd34tm1Szk/Cnbc
Alternative nameCD34
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCd34tm1Szk
Gene/Transgene symbolCd34

Information from provider

ProviderTak W Mak
Provider affiliationDivision of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute
Genetic informationDeletion of the transmembrane domain in Exon 7 of CD34.
Phenotypic informationCD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.
Breeding historyPure C57BL/6, backcrossed 10 times.
References
  • CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.;Suzuki A, Andrew D P, Gonzalo J A, Fukumoto M, Spellberg J, Hashiyama M, Takimoto H, Gerwin N, Webb I, Molineux G, Amakawa R, Tada Y, Wakeham A, Brown J, McNiece I, Ley K, Butcher E C, Suda T, Gutierrez-Ramos J C, Mak T W, ;1996;Blood;87;3550-62; 8611677
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6J males

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased cell proliferation / MGI
  • abnormal hair follicle morphology / MGI
  • abnormal epidermal layer morphology / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • increased skin papilloma incidence / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • decreased eosinophil cell number / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • integument phenotype / MGI
MGI phenotypes (gene matching)
  • decreased cell proliferation / MGI
  • abnormal hair follicle morphology / MGI
  • abnormal epidermal layer morphology / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • increased skin papilloma incidence / MGI
  • abnormal definitive hematopoiesis / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • decreased eosinophil cell number / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased erythroid progenitor cell number / MGI
  • decreased splenocyte number / MGI
  • integument phenotype / MGI

Literature references

  • CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.;Suzuki A, Andrew D P, Gonzalo J A, Fukumoto M, Spellberg J, Hashiyama M, Takimoto H, Gerwin N, Webb I, Molineux G, Amakawa R, Tada Y, Wakeham A, Brown J, McNiece I, Ley K, Butcher E C, Suda T, Gutierrez-Ramos J C, Mak T W, ;1996;Blood;87;3550-62; 8611677

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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