| Status | Available to order |
| EMMA ID | EM:07171 |
| Citation information | RRID:IMSR_EM:07171 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Cers4tm1.1Kwi/Cnrm |
| Alternative name | CerS4KILacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cers4tm1.1Kwi |
| Gene/Transgene symbol | Cers4 |
| Provider | Klaus Willecke |
| Provider affiliation | Molecular genetics, LIMES Institute, University of Bonn |
| Genetic information | The exons 2-11 of the Cers4 gene were replaced with a LacZ reporter gene followed by a FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in several tissues. LacZ expression is detected by staining with X-Gal. |
| Phenotypic information | Altered sphingolipid metabolism, alopecia. |
| Breeding history | Backcrossed to 93.8% C57BL/6. There occur no problems with homozygous breedings. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
