- abnormal hair follicle morphology / MGI
- alopecia / MGI
- enlarged sebaceous gland / MGI
- thick epidermis / MGI
- abnormal hair texture / MGI
- abnormal sebaceous gland physiology / MGI
- abnormal sebaceous lipid secretion / MGI
- hair follicle degeneration / MGI
- progressive hair loss / MGI
- abnormal sphingomyelin level / MGI
- abnormal ceramide level / MGI
STOCK Cers4tm1.1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:07171 |
International strain name | STOCK Cers4tm1.1Kwi/Cnrm |
Alternative name | CerS4KILacZ |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cers4tm1.1Kwi |
Gene/Transgene symbol | Cers4 |
Information from provider
Provider | Klaus Willecke |
Provider affiliation | Molecular genetics, LIMES Institute, University of Bonn |
Genetic information | The exons 2-11 of the Cers4 gene were replaced with a LacZ reporter gene followed by a FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in several tissues. LacZ expression is detected by staining with X-Gal. |
Phenotypic information | Altered sphingolipid metabolism, alopecia. |
Breeding history | Backcrossed to 93.8% C57BL/6. There occur no problems with homozygous breedings. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal hair follicle morphology / MGI
- alopecia / MGI
- enlarged sebaceous gland / MGI
- thick epidermis / MGI
- abnormal hair texture / MGI
- abnormal sebaceous lipid secretion / MGI
- hair follicle degeneration / MGI
- progressive hair loss / MGI
- abnormal sphingomyelin level / MGI
- abnormal ceramide level / MGI
- dilated piliary canal / MGI
Literature references
- Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.;Ebel Philipp, Imgrund Silke, Vom Dorp Katharina, Hofmann Kristina, Maier Helena, Drake Helena, Degen Joachim, Dörmann Peter, Eckhardt Matthias, Franz Thomas, Willecke Klaus, ;2014;The Biochemical journal;461;147-58; 24738593
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