STOCK Cers6tm1.1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:07170 |
International strain name | STOCK Cers6tm1.1Kwi/Cnrm |
Alternative name | CerS6KILacZ |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cers6tm1.1Kwi |
Gene/Transgene symbol | Cers6 |
Information from provider
Provider | Klaus Willecke |
Provider affiliation | Molecular genetics, LIMES Institute, University of Bonn |
Genetic information | A stop codon was inserted in the coding region of exon 7 followed by an IRES-LacZ reporter cassette. A FRT-flanked neo cassette was inserted upstream of exon 8. Flp-mediated recombination removed the neo cassette. LacZ expression is detected by staining with X-Gal. |
Phenotypic information | Behavioral impairment, altered sphingolipid metabolism. |
Breeding history | Backcrossed to 87.5% C57BL/6. There occur no problems with homozygous breedings. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal hippocampus morphology / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- limb grasping / MGI
- decreased inflammatory response / MGI
- abnormal lipid homeostasis / MGI
- increased vertical activity / MGI
- decreased circulating insulin level / MGI
- increased energy expenditure / MGI
- improved glucose tolerance / MGI
- behavior/neurological phenotype / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- enhanced lipolysis / MGI
- nervous / MGI
- microgliosis / MGI
- decreased brown fat cell lipid droplet size / MGI
- decreased fat cell size / MGI
- decreased total body fat amount / MGI
- abnormal cellular respiration / MGI
- abnormal habituation to a new environment / MGI
- abnormal ceramide level / MGI
- increased fatty acid oxidation / MGI
Literature references
- Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities.;Ebel Philipp, Vom Dorp Katharina, Petrasch-Parwez Elisabeth, Zlomuzica Armin, Kinugawa Kiyoka, Mariani Jean, Minich David, Ginkel Christina, Welcker Jochen, Degen Joachim, Eckhardt Matthias, Dere Ekrem, Dörmann Peter, Willecke Klaus, ;2013;The Journal of biological chemistry;288;21433-21447; 23760501
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