STOCK Tg(Sox2-Bgeo)1Skn/Cnrm
| Status | Available to order |
| EMMA ID | EM:07154 |
| Citation information | RRID:IMSR_EM:07154 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(Sox2-Bgeo)1Skn/Cnrm |
| Alternative name | Sox2 beta-geo telencephalic transgene |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Sox2-Bgeo)1Skn |
| Gene/Transgene symbol | Tg(Sox2-Bgeo)1Skn |
Information from provider
| Provider | Silvia Nicolis |
| Provider affiliation | University of Milano-Bicocca |
| Genetic information | This mouse carries a beta-geo transgene driven by the 5' region of Sox2 (promoter/enhancer), that directs expression to a specific subregion of the pan-neural expression domain of Sox2, i.e. the telencephalon. |
| Phenotypic information | Expression of the beta-geo transgene is seen in vivo in the telencephalon, and in vitro in neural stem cells cultured from the telencephalon, where expression is retained in long-term culture. Expression of this transgene marks telencephalic stem cells, as opposed to neural stem cells from different regions of the neural tube (e.g. spinal cord, that do not express it; Zappone M et al, Development 127:2367-2382, 2000). |
| Breeding history | The transgene was propagated by breeding carriers to cousins, or occasionally brothers/sisters |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells.;Zappone M V, Galli R, Catena R, Meani N, De Biasi S, Mattei E, Tiveron C, Vescovi A L, Lovell-Badge R, Ottolenghi S, Nicolis S K, ;2000;Development (Cambridge, England);127;2367-82; 10804179