| Status | Available to order |
| EMMA ID | EM:07149 |
| Citation information | RRID:IMSR_EM:07149 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(H2-K1-Ifnb1)10Seif Ifnar1tm1Agt/Orl |
| Alternative name | Ifnar1tm1Agt/Ifnar1tm1Agt Tg(H2-K1-Ifnb1)10Seif/Tg(H2- K1-Ifnb1)10Seif |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ifnar1tm1Agt, Tg(H2-K1-Ifnb1)10Seif |
| Gene/Transgene symbol | Ifnar1, Tg(H2-K1-Ifnb1)10Seif |
| Provider | Isabelle Seif |
| Provider affiliation | Neuropharmacologie, Faculte de pharmacie (Universite Paris-Sud) |
| Genetic information | Random integration of a transgene for IFN beta expressed under the control of a H2-K1 promoter resulted in insertion of the transgene into exon 2 of Prps1l3 and a partial duplication of Prps1l3 and Slc25a21, on chromosome 12. |
| Phenotypic information | Excess type I interferon signaling in the seminiferous tubules of Tg10 mice leads to germ cell loss and sterility. Testicular integrity and normal fertility is maintained in Tg10 mice invalidated for the type I IFN receptor (Tg10-Ifnar1-/-). |
| Breeding history | Inbred for 5 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | yes |
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C3H/He males, homozygous C3H/He females |
| Breeding at archiving centre | Males: transgenic for Tg(H2-K1-Ifnb1)10Seif and homozygous knock-out for Ifnar1-tm1Agt. Females: transgenic and homozygous knock-out. |
